Results 151 to 160 of about 10,355,590 (280)

Epigenomic modifications define chromatin states to regulate cell-free DNA fragmentomics. [PDF]

Nat Commun
Gong F, Pan Y, Lin H, An Y, Yang M, Liu X, Bai Y, Zhang Z, Tang B, Zhang K, Zhao X, Zhao Y, Du C, Shen X, Sun K.   +14 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Predictive Value of Perfusate Cell-free DNA During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys. [PDF]

Transplant Direct
Bousnina K, Slagter JS, Fang Y, Boers RG, Boers JB, Heidt S, van IJcken WFJ, Gribnau J, Minnee RC, Hoogduijn MJ, Boer K.   +10 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cell-free DNA fragmentomics for preeclampsia risk assessment. [PDF]

Nat Commun
Xu W, Chen S, Li J, Zhou S, Yin Y, Qiu Z, Zhang J, Liu C, Zhao Q, Xiao G, Zhou Y, Zhao Z, Zhang X, Yang W, Wang Y, Li H, Yang Z, Feng S, Zhang Q, Chen W, Li H, Ruan X, Li H, Zhang S, Hu L, Qin J, Huang W, Li Z, Cao X, Zhou X, Xu N, Hou D, Dong H, Wang J, Liu Y, Zhang Q, Wang X, Zhao L, Huang H, Xu C.   +39 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Serial Donor-derived Cell-free DNA Monitoring in a Kidney Transplant Recipient With Adenovirus Nephritis. [PDF]

Kidney Med
Xu EJ, Hirpara S, Kavcar AS, Jucha N, Sulejmani N, Pavlakis M, Rosen S, Pawar AS.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Utility of cell-free DNA in diagnosing tuberculous pleurisy: A systematic review and meta-analysis protocol. [PDF]

PLoS One
Shen Y, Du K, Ling Y, Yao L.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source