Results 161 to 170 of about 2,118,837 (302)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Epigenetic Instability-Based Metrics in Cell-Free DNA for Early Cancer Detection. [PDF]

Clin Cancer Res
Thursby SJ, Jin Z, Blum J, Gurau A, Noë M, Scharpf RB, Velculescu VE, Cope L, Brock M, Baylin S, Pisanic T, Easwaran H.   +11 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Diagnostic performance of donor-derived cell-free DNA for acute rejection in kidney allograft biopsies. [PDF]

J Bras Nefrol
Nakamura MR, Foresto RD, Gomes VRDS, Proença HM, Requião-Moura L, Medina-Pestana J, Tedesco-Silva H.   +6 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cancer-Like Fragmentomic Characteristics of Somatic Variants in Cell-Free DNA. [PDF]

Adv Sci (Weinh)
Zhang Z, An Y, Yang M, Pan Y, Liu X, Gong F, Lin H, Tang B, Bai Y, Zhao X, Zhao Y, Du C, Sun K.   +12 more
europepmc   +1 more source

Circulating Cell-Free DNA [PDF]

, 2020
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Donor-derived Cell-free DNA for Detection of Rejection After Pancreas Transplantation. [PDF]

Transplant Direct
Matar AJ, Riad S, Sarumi H, Megaly MG, Wright M, Finger E, Humphreville V, Ramanathan K, Fisher J, Rao JS, Demko Z, Prewett A, Tabriziani H, Kandaswamy R.   +13 more
europepmc   +1 more source