Results 181 to 190 of about 12,684,378 (242)

Epigenomic modifications define chromatin states to regulate cell-free DNA fragmentomics. [PDF]

Nat Commun
Gong F, Pan Y, Lin H, An Y, Yang M, Liu X, Bai Y, Zhang Z, Tang B, Zhang K, Zhao X, Zhao Y, Du C, Shen X, Sun K.   +14 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

MammaTrace - a tumor naïve cell-free DNA methylation test for minimal residual disease in breast cancer. [PDF]

NPJ Precis Oncol
Buckley DN, Kalfa AJ, Gooden G, Lewinger JP, Pacheco M, Gayton J, Spicer D, Carpten J, Stewart D, Lenz HJ, Hughes Halbert C, Lerman C, O'Shaughnessy J, Pockaj B, Salhia B.   +14 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Plasma Microbial Cell-Free DNA Sequencing for the Diagnosis of Chronic Disseminated Candidiasis in Patients with Hematologic Malignancies. [PDF]

Open Forum Infect Dis
De La Hoz A, Kovac V, Woolley AE, Issa NC, Letourneau A, Baden LR, Hammond SP, Little JS.   +7 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Circulating Cell-free DNA as a biomarker for radiation-induced injury: From mechanistic insights to clinical translation. [PDF]

Cancer Metastasis Rev
Sun Q, Li Y, Yin T, Teng F, Yu J.
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Cell-Free DNA and Mitochondria in Parkinson's Disease. [PDF]

Int J Mol Sci
Wojtkowska M, Ambrosius F.
europepmc   +1 more source