Results 171 to 180 of about 1,636,041 (314)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Data Sheet 1_Detection of lung allograft injury through a comprehensive multidisciplinary analysis of donor-derived cell-free DNA in plasma and bronchoalveolar lavage: a real-world single center experience.docx

Fiorella Calabrese (8732), Federica Pezzuto (11034759), Luca Vedovelli (9688365), Cecilia De Chellis (22188988), Francesca Lunardi (383509), Monica Loy (21086198), Eleonora Faccioli (22188991), Marta Vadori (22037888), Davide Biondini (2736265), Serena Marinello (11960646), Fausto Braccioni (6810755), Federica Meloni (2377684), Marco Schiavon (3777040), Chiara Giraudo (9361718), Claudia Del Vecchio (6104636), Deborah J. Levine (22188994), Emanuele Cozzi (9407893), Federico Rea (383513)   +17 more
openalex   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Genomic profiling of cell-free circulating tumor DNA in patients with colorectal cancer and its fidelity to the genomics of the tumor biopsy [PDF]

, 2019
Gerald Li, Dean C. Pavlick, Jon Chung, Todd M. Bauer, Bradford A. Tan, Julio Peguero, Patrick J. Ward, Andre M. Kallab, José A. Bufill, Anthony Hoffman, Ahad A. Sadiq, Jeff Edenfield, Jie He, Matthew B. Cooke, Jason D. Hughes, Brady Forcier, Michelle Nahas, Phil Stephens, Siraj M. Ali, Alexa B. Schrock, Jeffrey S. Ross, Vincent A. Miller, Jeffrey P. Gregg   +22 more
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cell-Free DNA-Derived Immune Cell Ratios Uncover Cancer-Associated Systemic Changes. [PDF]

Cancer Res Commun
Andersen L, Lindskrog SV, Nordentoft I, Frydendahl A, Nors J, Henriksen TV, Rasmussen MH, Iversen LH, Gotschalck KA, Jensen JB, Dyrskjøt L, Andersen CL, Birkbak NJ.   +12 more
europepmc   +1 more source

Referee report. For: Donor-derived circulating cell-free DNA as a rejection biomarker and modulator of immunosuppression following liver transplantation: A randomized controlled trial [version 1; peer review: 1 approved]

Roma Raj
openalex   +1 more source

Circulating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer

, 2016
Bo Ai, Huiquan Liu, Yu Huang, Ping Peng
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multimodal analysis of cell-free DNA identifies epigenetic biomarkers for amyotrophic lateral sclerosis diagnosis and progression. [PDF]

J Clin Invest
Michels S, Chen C, Ruf WP, Garcia Garcia MM, Arnold FJ, Wu Z, Bennett CL, Shams D, Thompson LM, Walker AC, Dickson DW, Petrucelli L, Dorst J, Prudencio M, Li W, La Spada AR.   +15 more
europepmc   +1 more source