Results 271 to 280 of about 1,636,041 (314)

Cell-free DNA

Anais do 6º Simpósio de Saúde: Saúde 4.0 - Tecnologia e Inovação, 2023
O DNA livre de células, ou cfDNA, tem sido cada vez mais reconhecido como um biomarcador importante em diversas áreas da medicina.
Diogo Barcelos Almeida, Bárbara Stefanie de Souza Scodeler, Kelly Dos Santos Gonçalves, Maria Júlia Sá, Leiridiane Martins, Gabrielle Alves de Paiva, André Luís Braghini Sá   +6 more
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Cell-Free DNA in Dermatology Research

Journal of Investigative Dermatology, 2022
In various diseases, particularly cancer, cell-free DNA (cfDNA) has been widely studied as a marker of disease prognosis or to facilitate the detection of therapeutic targets. In dermatology, most studies have focused on melanoma; other skin diseases such as vascular malformations and psoriasis have also been examined. Genetic alterations unique to the
Jennifer M. Wiggins, Saim Ali, David Polsky   +2 more
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Cell-free DNA: Preanalytical variables

Clinica Chimica Acta, 2015
Since the discovery of cell-free DNA (cfDNA) in human blood, most studies have focused on diagnostic and prognostic uses of these markers for solid tumors. Except for some prenatal tests and BEAMing, cfDNA analysis has not yet been translated to clinical practice and routine application appears distant. This can be attributed to overlapping factors: (i)
Abel Jacobus Bronkhorst, Janine Aucamp, Piet J. Pretorius   +2 more
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Adipose cell-free DNA in diabetes

Clinica Chimica Acta, 2023
Cancer-associated necrosis is a well-known source of cell-free DNA (cfDNA). However, the origins of cfDNA are not strictly limited to cancer. Additionally, dietary exposure induces apoptosis-induced proliferation in adipocytes, leading to the release of cfDNA.
Humardani, Farizky Martriano, Mulyanata, Lisa Thalia, Putra, Sulistyo Emantoko Dwi   +2 more
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Application of cell free DNA in ART

Placenta, 2022
Various biopsy and sampling methods are used for preimplantation genetic diagnosis (PGD) of embryo. This method benefits blastomer/trophectoderm biopsy to improve the clinical outcome of in vitro fertilization (IVF). However, all of these procedures are invasive and have adverse effects on embryo development.
Amin Alizadegan, Hassan Dianat-Moghadam, Nasrin Shadman, Mohammad Nouri, Kobra Hamdi, Alieh Ghasemzadeh, Maryam Akbarzadeh, Parisa Sarvarian, Amir Mehdizadeh, Sanam Dolati, Mehdi Yousefi   +10 more
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Cell-free DNA in 2030

Med
The analysis of cell-free DNA (cfDNA) has emerged as a cornerstone of minimally invasive liquid biopsies. We summarize the key advancements of the last five years-deepening insights into fundamental cfDNA biology, innovations in wet- and dry-lab approaches, and the amassment of clinical outcome data-and discuss prospects of this field for the coming ...
W H Adrian, Tsui, Y M Dennis, Lo
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Cell-Free DNA

2019
Cell-free DNA (cfDNA) found in the plasma or serum is derived from multiple sources, including tumor cells. The fraction of cfDNA derived from tumor cells is termed circulating tumor DNA (ctDNA). Despite the low levels of ctDNA in normal cfDNA, advances in digital polymerase chain reaction (PCR) and next-generation sequencing (NGS) technologies have ...
Hiroyuki Yamamoto, Yoshiyuki Watanabe, Fumio Itoh   +2 more
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Cell-free DNA Screening for Aneuploidy

Clinical Obstetrics & Gynecology, 2023
Cell-free DNA (cfDNA) screening has high detection for the common fetal autosomal aneuploidies, but is not diagnostic. The positive predictive value should be utilized in counseling after a positive cell-free DNA screen, and diagnostic testing should be offered for confirmation.
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Cell-Free DNA in Hematologic Malignancies

JCO Oncology Practice
Liquid biopsy techniques using cell-free DNA (cfDNA) play an increasingly important role in the characterization and surveillance of solid tumors. For blood cancers, molecular response assessment techniques using circulating malignant cells or bone marrow aspirates are well established in clinical care. However, cfDNA has an emerging role in hematology
Joseph G. Schroers-Martin, Ash A. Alizadeh   +1 more
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Circulating cell free DNA: Preanalytical considerations

Clinica Chimica Acta, 2013
Despite the growing interest in circulating cell-free DNA (ccfDNA) analysis in various clinical fields, especially oncology and prenatal diagnosis, few studies on sample handling have been reported and no analytical consensus is available. The lack of consistency between the various protocols for sample handling and the techniques used for ccfDNA ...
El Messaoudi, Safia, Rolet, Fanny, Mouliere, F.; id_orcid 0000-0001-7043-0514, Thierry, Alain R.   +3 more
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