Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application. [PDF]
Int J Mol Sci, 2020 Liquid biopsy recently became a very promising diagnostic method that has several advantages over conventional invasive methods. Liquid biopsy may serve as a source of several important biomarkers including cell-free nucleic acids (cf-NAs). Cf-DNA is widely used in prenatal testing in order to characterize fetal genetic disorders.
Szilágyi M +8 more
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Circulating cell-free nucleic acids: characteristics and applications. [PDF]
Eur J Hum Genet, 2018 Liquid biopsy is becoming a very popular sample obtaining procedure, replacing the invasive sampling methods for the diagnostic protocols. The advantages of this method include the possibility to isolate cell-free nucleic acids (cfNAs) for diagnostic or screening purposes.
Pös O, Biró O, Szemes T, Nagy B.
europepmc +4 more sources
Precise, Orthogonal Remote-Control of Cell-Free Systems Using Photocaged Nucleic Acids
Journal of the American Chemical Society, 2023 Cell-free expression of a gene to protein has become a vital tool in nanotechnology and synthetic biology. Remote-control of cell-free systems with multiple, orthogonal wavelengths of light would enable precise, non-invasive modulation, opening many new applications in biology and medicine.
Giacomo Mazzotti +2 more
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Integrated analysis of circulating cell free nucleic acids for cancer genotyping and immune phenotyping of tumor microenvironment [PDF]
Frontiers in Genetics, 2023 The circulating cell-free nucleic acids (ccfNAs) consist of a heterogenous cocktail of both single (ssNA) and double-stranded (dsNA) nucleic acids. These ccfNAs are secreted into the blood circulation by both healthy and malignant cells via various ...
Muskan Chaddha +3 more
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Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders [PDF]
Frontiers in Physiology, 2018 Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common cause of chronic liver pathology, which prevalence strongly correlates with the increasing incidence of diabetes, obesity and metabolic syndrome in the general population.
Andrey Turchinovich +8 more
doaj +2 more sources
Cell-Free Nucleic Acids in Cardiovascular Disease: From Biomarkers to Mechanistic Drivers and Therapeutic Opportunities [PDF]
CellsCardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, with heart failure (HF) representing a major contributor to hospitalizations, healthcare costs, and death.
Hannah Morgan +10 more
doaj +2 more sources
Evaluation of circulating cell-free nucleic acids in plasma as biomarkers of laryngeal cancer [PDF]
Cellular, Molecular and Biomedical ReportsIt has been aimed to compare the level of cell-free nucleic acids (DNA, RNA, and miRNA) concentrations in laryngeal cancer patients with the control group composed of healthy individuals. It has been utilized 46 patients with laryngeal carcinoma who were
Basak Yavuz, Ozge Cil, Akin Cayir
doaj +2 more sources
Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes
Translational OncologyClinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as cancer.
Ahmad Salman Sirajee +2 more
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Expression of circulating cell-free nucleic acids around miniscrew implant during orthodontic tooth movement-a prospective study. [PDF]
Prog Orthod, 2021 Qureshi T +3 more
europepmc +3 more sources
Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies. [PDF]
Oncotarget, 2020 Clark ME +15 more
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