Results 271 to 280 of about 142,957 (305)

The Pharmacokinetics of Cell-Penetrating Peptides

Molecular Pharmaceutics, 2010
Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko, Barbro, Beijer, Regine, Garcia Boy, Eva-Maria, Nothelfer, Karin, Leotta, Michael, Eisenhut, Annette, Altmann, Uwe, Haberkorn, Walter, Mier   +8 more
openaire   +2 more sources

Predicting cell-penetrating peptides

Advanced Drug Delivery Reviews, 2008
Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Mats, Hansen, Kalle, Kilk, Ulo, Langel
openaire   +2 more sources

Prediction of Cell-Penetrating Peptides

2015
The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
openaire   +2 more sources

Studying the uptake of cell-penetrating peptides

Nature Protocols, 2006
More than a decade ago, it was discovered that cationic peptides could traverse the cellular plasma membrane without specific transporter proteins or membrane damage. Subsequently, it was found that these peptides, known as cell-penetrating peptides (CPPs), were also capable of delivering cargos into cells, hence the great potential of these vectors ...
Tina, Holm, Henrik, Johansson, Pontus, Lundberg, Margus, Pooga, Maria, Lindgren, Ulo, Langel   +5 more
openaire   +2 more sources

Cell Penetrating Peptides for Tumor Targeting

Current Pharmaceutical Biotechnology, 2011
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy.
Young Suk, Choi, Jue Yeon, Lee, Jin Sook, Suh, Seung Jin, Lee, Victor C, Yang, Chong Pyoung, Chung, Yoon Jeong, Park   +6 more
openaire   +2 more sources

Therapeutic Potential of cell-penetrating Peptides

Therapeutic Delivery, 2013
The ability of cell-penetrating peptides to cross plasma membranes has been used for various applications, including the delivery of bioactive molecules to inhibit disease-producing cellular mechanisms. Selective drug delivery into target cells improves drug distribution and decreases dosing and toxicity.
Luís, Vasconcelos, Kalle, Pärn, Ulo, Langel   +2 more
openaire   +2 more sources

Synthesis and Studies on Cell-Penetrating Peptides

Bioconjugate Chemistry, 2009
The ability of different synthetic cell penetrating peptides, as Antennapedia (wild and Phe(6) mutated penetratins), flock house virus, and integrin peptides to form complexes with a 25mer antisense oligonucleotide was compared and their conformation was determined by circular dichroism spectroscopy.
Jean-Remi, Bertrand, Claude, Malvy, Tiphanie, Auguste, Gábor K, Tóth, Orsolya, Kiss-Ivánkovits, Eszter, Illyés, Miklós, Hollósi, Sándor, Bottka, Ilona, Laczkó   +8 more
openaire   +2 more sources

Properties and Applications of Cell-Penetrating Peptides

2004
Cell-penetrating peptides (CPPs) are water-soluble molecules with sequences containing some cationic (basic) residues but have the ability to translocate through various cell plasma membranes with high efficiency and low lytic activity, and seemingly without any chiral receptor.
A, Gräslund, L E G, Eriksson
openaire   +2 more sources

Cell Penetrating Peptides in Drug Delivery

Pharmaceutical Research, 2004
Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism.
Eric L, Snyder, Steven F, Dowdy
openaire   +2 more sources

Therapeutic Applications of Cell-Penetrating Peptides

2010
Since the discovery over 15 years ago of a protein transcription factor that possessed the ability to cross the plasma membrane, cell-penetrating peptides (CPPs) have been evaluated for the ability to transport diverse cargoes into cells, tissues, and organs.
Randolph M, Johnson, Stephen D, Harrison, Derek, Maclean   +2 more
openaire   +2 more sources