Results 21 to 30 of about 395,472 (375)

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Current peptide antigen vaccine strategies have shown modest success in eliciting robust T cell priming. We defined mechanisms of action for a promising strategy based on covalently linking peptide antigens to cell-penetrating peptides (CPPs)
Coralie M Backlund, Rebecca L. Holden, K. Moynihan, Daniel Garafola, C. Farquhar, Naveen K Mehta, L. Maiorino, Sydney Pham, J. Iorgulescu, D. Reardon, Catherine J. Wu, B. Pentelute, D. Irvine   +12 more
semanticscholar   +1 more source

Glycosylated Cell‐Penetrating Peptides (GCPPs) [PDF]

ChemBioChem, 2019
AbstractThe cell membrane regulates the exchange of molecules and information with the external environment. However, this control barrier hinders the delivery of exogenous bioactive molecules that can be applied to correct cellular malfunctions. Therefore, the traffic of macromolecules across the cell membrane represents a great challenge for the ...
Iván Gallego, Alicia Rioboo, José J. Reina, Bernardo Díaz, Ángeles Canales, F. Javier Cañada, Jorge Guerra‐Varela, Laura Sánchez, Javier Montenegro   +8 more
openaire   +4 more sources

Optimizing Antimicrobial Peptide Design: Integration of Cell-Penetrating Peptides, Amyloidogenic Fragments, and Amino Acid Residue Modifications. [PDF]

Int J Mol Sci
Kravchenko SV, Domnin PA, Grishin SY, Zakhareva AP, Zakharova AA, Mustaeva LG, Gorbunova EY, Kobyakova MI, Surin AK, Poshvina DV, Fadeev RS, Azev VN, Ostroumova OS, Ermolaeva SA, Galzitskaya OV.   +14 more
europepmc   +3 more sources

Tricyclic Cell-Penetrating Peptides for Efficient Delivery of Functional Antibodies into Cancer Cells

Nature Chemistry, 2021
The intracellular environment hosts a large number of cancer- and other disease-relevant human proteins. Targeting these with internalized antibodies would allow therapeutic modulation of hitherto undruggable pathways, such as those mediated by protein ...
O. Tietz, Fernando Cortezon-Tamarit, R. Chalk, S. Able, K. Vallis   +4 more
semanticscholar   +1 more source

Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space

Scientific Reports, 2021
Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that protects cells. These peptides share common structural and physicochemical properties and show different pharmaceutical applications, among which drug delivery ...
Ewerton Cristhian Lima de Oliveira, Kauê Santana, L. Josino, A. H. Lima e Lima, Claudomiro de Souza de Sales Júnior   +4 more
semanticscholar   +1 more source

Chemical-functional diversity in cell-penetrating peptides. [PDF]

PLoS ONE, 2013
Cell-penetrating peptides (CPPs) are a promising tool to overcome cell membrane barriers. They have already been successfully applied as carriers for several problematic cargoes, like e.g.
Sofie Stalmans, Evelien Wynendaele, Nathalie Bracke, Bert Gevaert, Matthias D'Hondt, Kathelijne Peremans, Christian Burvenich, Bart De Spiegeleer   +7 more
doaj   +1 more source

Arginine‐rich cell‐penetrating peptides [PDF]

FEBS Letters, 2009
Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a
Schmidt, Nathan, Mishra, Abhijit, Lai, Ghee Hwee, Wong, Gerard C.L.   +3 more
openaire   +2 more sources

Editorial on Special Issue “Precision Delivery of Drugs and Imaging Agents with Peptides”

Pharmaceutics, 2022
Homing peptides and cell-penetrating peptides allow for systemic targeting of diseased tissues and/or efficient intracellular delivery of payloads [...]
Kaido Kurrikoff, Tambet Teesalu
doaj   +1 more source

Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics

Antibiotics, 2022
Antimicrobial peptides (AMPs) are short oligopeptides that can penetrate the bacterial inner and outer membranes. Together with cell-penetrating peptides (CPPs), they are called membrane active peptides; peptides which can translocate across biological ...
A. Hadjicharalambous, Nikolaos Bournakas, H. Newman, Michael J. Skynner, Paul Beswick   +4 more
semanticscholar   +1 more source

Antimicrobial Peptides and Cell-Penetrating Peptides for Treating Intracellular Bacterial Infections

Frontiers in Cellular and Infection Microbiology, 2021
Bacterial infections caused by intracellular pathogens are difficult to control. Conventional antibiotic therapies are often ineffective, as high doses are needed to increase the number of antibiotics that will cross the host cell membrane to act on the ...
D. F. Buccini, M. H. Cardoso, O. L. Franco   +2 more
semanticscholar   +1 more source