Results 121 to 130 of about 26,893,016 (421)

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

Genome Biology, 2006
Biologists can now prepare and image thousands of samples per day using automation, enabling chemical screens and functional genomics (for example, using RNA interference).
Anne E Carpenter, T. Jones, M. R. Lamprecht, C. Clarke, In Han Kang, O. Friman, D. Guertin, Joo Han Chang, Robert A Lindquist, J. Moffat, P. Golland, D. Sabatini   +11 more
semanticscholar   +1 more source

Single-cell transcriptomics : a high-resolution avenue for plant functional genomics [PDF]

, 2019
Plant function is the result of the concerted action of single cells in different tissues. Advances in RNA-seq technologies and tissue processing allow us now to capture transcriptional changes at single-cell resolution.
Finch, Jessica A., Lucas, Emma S., Ott, Sascha, Rich-Griffin, Charlotte, Schäfer, Patrick, Stechemesser, Annika   +5 more
core   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Regulative Differentiation as Bifurcation of Interacting Cell Population [PDF]

arXiv, 2007
In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a mechanism for cell differentiation with regulation of populations of each cell type by taking simple cell models with ...
arxiv  

Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.

Molecular Biology of the Cell, 1998
We sought to create a comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle. To this end, we used DNA microarrays and samples from yeast cultures synchronized by three independent methods: alpha factor ...
P. Spellman, G. Sherlock, Michael Ruogu Zhang, V. Iyer, Klaus E. Anders, M. Eisen, P. Brown, D. Botstein, B. Futcher   +8 more
semanticscholar   +1 more source

Macroscopic limits of individual-based models for motile cell populations with volume exclusion [PDF]

, 2012
Partial differential equation models are ubiquitous in studies of motile cell populations, giving a phenomenological description of events which can be analyzed and simulated using a wide range of existing tools.
Baker, R. E., Dyson, L, Maini, P. K.
core   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Fetal RHD Genotyping Using Real-Time Polymerase Chain Reaction Analysis of Cell-Free Fetal DNA in Pregnancy of RhD Negative Women in South of Iran [PDF]

International Journal of Fertility and Sterility, 2016
Background Maternal-fetal RhD antigen incompatibility causes approximately 50% of clinically significant alloimmunization cases. The routine use of prophylactic anti-D immunoglobulin has dramatically reduced hemolytic disease of the fetus and newborn ...
Leili Moezzi, Zeinab Keshavarz, Reza Ranjbaran, Farzaneh Aboualizadeh, Abbas Behzad-Behbahani, Masooma Abdullahi, Amin Ramezani, Alamtaj Samsami, Sedigheh Sharifzadeh   +8 more
doaj   +1 more source

Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model [PDF]

arXiv, 2018
We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source