Results 121 to 130 of about 5,922,620 (255)
Carbamylated low-density lipoprotein and adhesion molecules
, 2016 Carbamylated LDL (cLDL), the most abundant modifi ed LDL isoform in human blood, has been recently implicated in causing atherosclerosis-prone injuries to endothelial cells in vitro and atherosclerosis in patients with chronic kidney disease.
Basnakian A.G. +3 more
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
CELL ADHESION MOLECULES: AN OVERVIEW [PDF]
Rheumatology, 1995 A, Laffón, R, González-Amaro
openaire +2 more sources
Direct Observation of Catch Bonds Involving Cell-Adhesion Molecules
, 2003 Bonds between adhesion molecules are often mechanically stressed. A striking example is the tensile force applied to selectin-ligand bonds, which mediate the tethering and rolling of flowing leukocytes on vascular surfaces(1-3).
Yago T +5 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis
International Journal of Cell Biology, 2012 Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ.
Chee Wai Wong +2 more
doaj +1 more source
Effects of fatty acids on inflammatory markers studied in vivo and in vitro
, 2008 Inflammation involves interactions amongst many different cell types as a defense mechanism of the body. Inflammation is also involved in cardiovascular disease (CVD).
Mohd Yusof, Hayati
core +1 more source
PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility
, 2020 Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Yaw-Dong Lang +3 more
core +1 more source