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Synaptic Cell Adhesion Molecules
2012During development of the nervous system following axon pathfinding, synaptic connections are established between neurons. Specific cell adhesion molecules (CAMs) accumulate at pre- and postsynaptic sites and trigger synaptic differentiation through interactions with intra- and extracellular scaffolds. These interactions are important to align pre- and
Olena, Bukalo, Alexander, Dityatev
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Cell adhesion molecules and the kidney
Pediatric Nephrology, 1994Cell adhesion molecules (CAMs) have been implicated in various biologic processes, including morphogenesis, immune response, and thrombosis. There are four major groups: integrins, cadherins, immunoglobulin superfamily members, and selectins. Certain CAMs are differentially expressed in the developing, normal, and cancerous kidney.
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Cell adhesion molecules in vasculitis
Current Opinion in Rheumatology, 1997Activation of the vascular endothelium by several different stimuli plays a crucial role in the initiation, localization, and propagation of vascular injury. In vitro studies have demonstrated that activation of cultured vascular endothelial cells renders them hyperadhesive for leukocytes.
J W, Tervaert, C G, Kallenberg
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Cell adhesion molecules at the synapse
Frontiers in Bioscience, 2006Synapses are specialized intercellular junctions whose specificity and plasticity provide the structural and functional basis for the formation and maintenance of the complex neural network in the brain. The number, location, and type of synapses formed are well controlled, since synaptic circuits are formed in a highly reproducible way.
Kimberly, Gerrow, Alaa, El-Husseini
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Adhesion molecules in cell interactions
Current Opinion in Immunology, 1993During a successful immune response, several families of adhesion molecules participate in a cascade of binding events that lead to the binding of leukocytes, both to each other and to cell types such as the endothelium and epithelium. A central theme emerging from recent studies is that the function of an adhesion receptor cannot be inferred from its ...
N, Hogg, R C, Landis
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Cell adhesion molecules and cancer
Current Opinion in Oncology, 1992Cell adhesion molecules are complex protein and carbohydrate molecules of many different types found on the surfaces of all cells. They are important in many aspects of cell biology including development, differentiation, and motility. These processes are frequently disturbed in cancer and recent work has demonstrated that disturbances in cell adhesion
J, Fawcett, A L, Harris
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Glycosyltransferases as cell adhesion molecules
Current Opinion in Cell Biology, 1993Specific glycosyltransferases are believed to be present on the cell surface, where they may function as cell adhesion molecules by binding oligosaccharide substrates on adjacent cell surfaces or in the extracellular matrix. The best studied of these is beta 1,4-galactosyltransferase, which mediates sperm binding to the egg coat and selected cell ...
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Cell Adhesion Molecules and Endometriosis
Seminars in Reproductive Medicine, 2003The pathogenesis of endometriosis remains poorly defined. The interaction of endometrium with peritoneum is an important aspect of the disease process. Cell adhesion molecules (CAMs) are transmembrane receptors that facilitate intercellular binding and cellular interaction with the extracellular matrix (ECM).
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Epithelial cell adhesion molecules
Experimental Cell Research, 1986Recognition and binding between cells are of fundamental importance for a proper function of multicellular organisms, both during embryonic development and in the adult stage. Recently several cell surface proteins that are involved in these phenomena have been discovered.
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