Results 1 to 10 of about 14,155,031 (371)
Cell Cycle Commitment and the Origins of Cell Cycle Variability [PDF]
Frontiers in Cell and Developmental Biology, 2021 Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a ...
Robert F. Brooks, Robert F. Brooks
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Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov +17 more
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
R. Kumari, P. Jat
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Тенденции развития науки и образования, 2023 The cell cycle is part of a general complex of processes that include ensuring the stability of the genetic material. If the cell cycle is disturbed, DNA synthesis is delayed, mitosis does not begin until the completion of replication, and is blocked in ...
Y.V. Kornitskaya +2 more
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The Oncologist, 2000 The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
Esther D. Israels, L.G. Israels
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 ‘Dividing cells pass through a regular sequence of cell growth and division, known as the cell cycle’, according to a college textbook of biology published in 1983 [[1][1]], 5 years before the underlying principles of control were first laid bare during 1988, the annus mirabilis of cell ...
Hunt, T, Nasmyth, K, Novák, B
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Epigenetics & Chromatin, 2022 Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro +5 more
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DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
Cell Death Discovery, 2023 Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan +9 more
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The Influence of Cell Cycle Regulation on Chemotherapy
International Journal of Molecular Sciences, 2021 Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair.
Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu
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Discover Oncology, 2023 Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integration into human
Garima Singh +3 more
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