Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle [PDF]
Nature CommunicationsCell cycle events are ordered by cyclin-dependent kinases (CDKs), which phosphorylate hundreds of substrates. Multiple phosphatases oppose these CDK substrates, yet their collective role in regulating phosphorylation timing in vivo remains unclear. Here,
Theresa U. Zeisner +3 more
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Epigenetics & Chromatin, 2022 Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro +5 more
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DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
Cell Death Discovery, 2023 Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan +9 more
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iScience, 2022 Summary: The MAP kinase Sty1 phosphorylates and activates the transcription factor Atf1 in response to several stress conditions, which then shifts from a transcriptional repressor to an activator.
Rodrigo Fraile +4 more
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Discover Oncology, 2023 Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integration into human
Garima Singh +3 more
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Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila
Nature Communications, 2022 The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear.
Pénélope Darnat +6 more
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miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells
BMC Cancer, 2022 MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by ...
Garima Singh +2 more
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A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
eLife, 2022 Spatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors.
Jérôme Lacoste +6 more
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ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2020 DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin +10 more
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Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
Nature Communications, 2016 The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C ...
Francesco Meghini +6 more
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