Results 1 to 10 of about 3,250,873 (259)

The contribution of age structure to cell population responses to targeted therapeutics [PDF]

Journal of Theoretical Biology, 2012, 311, pp.19-27, 2011
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position.
Ackleh, Ackleh, Ainseba, Ainseba, Alarcón, Angulo, Angulo, Arino, Banks, Bekkal Brikci, Bekkal Brikci, Bernard, Calsina, Darren R. Tyson, Diekmann, Douglas, Doumic, Doumic, Dowling, Engel, Engl, Gabriel, Gabriel, Gerlee, Glenn F. Webb, Golubev, Gyllenberg, Gyllenberg, Gyllenberg, Hinow, Kostova, Lee, Liu, Mallet, Michel, Patel, Perthame, Perthame, Picart, Picart, Pierre Gabriel, Pilant, Pilant, Powathil, Quaranta, Quaranta, Ramis-Conde, Ribba, Rundell, Rundell, Shawn P. Garbett, Vito Quaranta, Webb   +52 more
arxiv   +8 more sources

Modelling radiation-induced cell cycle delays [PDF]

Published online: Radiation and Environmental Biophysics, 2009. The original publication is available at http://www.springerlink.com/content/l33041651m10815w/, 2009
Ionizing radiation is known to delay the cell cycle progression. In particular after particle exposure significant delays have been observed and it has been shown that the extent of delay affects the expression of damage such as chromosome aberrations.
AD Virgilio, Anna Ochab-Marcinek, B Basse, E Erba, E Gudowska-Nowak, Elena Nasonova, Ewa Gudowska-Nowak, F Montalenti, FA Cucinotta, G Kaufman, G Wilson, L Li, M Kohandel, M Scholz, M Scholz, M Scholz, M Zaider, N Hartmann, P Flatt, P Hahnfeldt, R Lee, R Mateuca, R Pathak, R Purrot, S Engen, S Ritter, S Ritter, S Tenhumberg, Sylvia Ritter, T Groesser, U Amaldi, W Chaung, W Feller, W Weyrather, WK Sinclair   +34 more
arxiv   +3 more sources

Cell Cycle Commitment and the Origins of Cell Cycle Variability [PDF]

Frontiers in Cell and Developmental Biology, 2021
Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a ...
Robert F. Brooks, Robert F. Brooks
openaire   +9 more sources

The Cell Cycle [PDF]

The Oncologist, 2000
The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
Esther D. Israels, L.G. Israels
openaire   +4 more sources

The cell cycle [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
‘Dividing cells pass through a regular sequence of cell growth and division, known as the cell cycle’, according to a college textbook of biology published in 1983 [[1][1]], 5 years before the underlying principles of control were first laid bare during 1988, the annus mirabilis of cell ...
Hunt, T, Nasmyth, K, Novák, B
openaire   +2 more sources

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development

Epigenetics & Chromatin, 2022
Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza   +5 more
doaj   +1 more source

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Cell Death Discovery, 2023
Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J. Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas   +9 more
doaj   +1 more source

miR-17 ~ 92 suppresses proliferation and invasion of cervical cancer cells by inhibiting cell cycle regulator Cdt2

Discover Oncology, 2023
Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integration into human
Garima Singh, Sonika Kumari Sharma, Aastha Dorata, Samarendra Kumar Singh   +3 more
doaj   +1 more source

Phasing in on the cell cycle [PDF]

Cell Division, 2018
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions. Moreover, this discovery has provided a new framework for the study of membrane-less organelle biogenesis and protein ...
Ludo Van Den Bosch, Steven Boeynaems, Steven Boeynaems, Peter Tompa, Peter Tompa   +4 more
openaire   +5 more sources

The Cell Cycle is a Limit Cycle [PDF]

Mathematical Modelling of Natural Phenomena, 2012
Progression along the successive phases of the mammalian cell cycle is driven by a network of cyclin-dependent kinases (Cdks). This network is regulated by a variety of negative and positive feedback loops. We previously proposed a detailed, 39-variable model for the Cdk network and showed that it is capable of temporal self-organization in the form of
Albert Goldbeter, Claude Gérard, Claude Gérard   +2 more
openaire   +1 more source