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Тенденции развития науки и образования, 2023 The cell cycle is part of a general complex of processes that include ensuring the stability of the genetic material. If the cell cycle is disturbed, DNA synthesis is delayed, mitosis does not begin until the completion of replication, and is blocked in anaphase, if the attachment of chromosomes to the mitotic spindle is disturbed.
Y.V. Kornitskaya +2 more
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Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle [PDF]
Nature CommunicationsCell cycle events are ordered by cyclin-dependent kinases (CDKs), which phosphorylate hundreds of substrates. Multiple phosphatases oppose these CDK substrates, yet their collective role in regulating phosphorylation timing in vivo remains unclear. Here,
Theresa U. Zeisner +3 more
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Cell Reports, 2017 Cell cycle kinetics are crucial to cell fate decisions. Although live imaging has provided extensive insights into this relationship at the single-cell level, the limited number of fluorescent markers that can be used in a single experiment has hindered ...
Thomas Zerjatke +8 more
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
R. Kumari, P. Jat
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Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
P. Tsvetkov +17 more
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Cell cycle regulation: p53-p21-RB signaling
Cell Death and Differentiation, 2022 The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
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Targeting cell-cycle machinery in cancer.
Cancer Cell, 2021 Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins regulate a wide range of cellular functions, in addition to ...
Jan M. Suski +3 more
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Cell cycle on the crossroad of tumorigenesis and cancer therapy.
Trends in Cell Biology, 2021 Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic targets.
Jing Liu, Yunhua Peng, Wenyi Wei
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The Influence of Cell Cycle Regulation on Chemotherapy
International Journal of Molecular Sciences, 2021 Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair.
Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Epigenetics & Chromatin, 2022 Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro +5 more
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