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Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns [PDF]
Genome BiologyBackground The selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well defined.
Tyler D. Noble +4 more
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
R. Kumari, P. Jat
semanticscholar +1 more source
Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov +17 more
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Cell cycle regulation: p53-p21-RB signaling
Cell Death and Differentiation, 2022 The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
semanticscholar +1 more source
Тенденции развития науки и образования, 2023 The cell cycle is part of a general complex of processes that include ensuring the stability of the genetic material. If the cell cycle is disturbed, DNA synthesis is delayed, mitosis does not begin until the completion of replication, and is blocked in ...
Y.V. Kornitskaya +2 more
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Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development
Epigenetics & Chromatin, 2022 Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro +5 more
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DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints
Cell Death Discovery, 2023 Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the ...
Lucía San Juan +9 more
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iScience, 2022 Summary: The MAP kinase Sty1 phosphorylates and activates the transcription factor Atf1 in response to several stress conditions, which then shifts from a transcriptional repressor to an activator.
Rodrigo Fraile +4 more
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The Influence of Cell Cycle Regulation on Chemotherapy
International Journal of Molecular Sciences, 2021 Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair.
Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu
semanticscholar +1 more source
Discover Oncology, 2023 Cervical cancer (CC) is the 4th most leading cause of death among women worldwide, and if diagnosed in late stages the treatment options are almost negligible. 99% of CC is caused by high-risk human papilloma viruses (HR-HPV). Upon integration into human
Garima Singh +3 more
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