Results 11 to 20 of about 15,988,239 (410)

Modelling radiation-induced cell cycle delays [PDF]

Published online: Radiation and Environmental Biophysics, 2009. The original publication is available at http://www.springerlink.com/content/l33041651m10815w/, 2009
Ionizing radiation is known to delay the cell cycle progression. In particular after particle exposure significant delays have been observed and it has been shown that the extent of delay affects the expression of damage such as chromosome aberrations.
AD Virgilio, Anna Ochab-Marcinek, B Basse, E Erba, E Gudowska-Nowak, Elena Nasonova, Ewa Gudowska-Nowak, F Montalenti, FA Cucinotta, G Kaufman, G Wilson, L Li, M Kohandel, M Scholz, M Scholz, M Scholz, M Zaider, N Hartmann, P Flatt, P Hahnfeldt, R Lee, R Mateuca, R Pathak, R Purrot, S Engen, S Ritter, S Ritter, S Tenhumberg, Sylvia Ritter, T Groesser, U Amaldi, W Chaung, W Feller, W Weyrather, WK Sinclair   +34 more
arxiv   +3 more sources

The contribution of age structure to cell population responses to targeted therapeutics [PDF]

Journal of Theoretical Biology, 2012, 311, pp.19-27, 2011
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position.
Ackleh, Ackleh, Ainseba, Ainseba, Alarcón, Angulo, Angulo, Arino, Banks, Bekkal Brikci, Bekkal Brikci, Bernard, Calsina, Darren R. Tyson, Diekmann, Douglas, Doumic, Doumic, Dowling, Engel, Engl, Gabriel, Gabriel, Gerlee, Glenn F. Webb, Golubev, Gyllenberg, Gyllenberg, Gyllenberg, Hinow, Kostova, Lee, Liu, Mallet, Michel, Patel, Perthame, Perthame, Picart, Picart, Pierre Gabriel, Pilant, Pilant, Powathil, Quaranta, Quaranta, Ramis-Conde, Ribba, Rundell, Rundell, Shawn P. Garbett, Vito Quaranta, Webb   +52 more
arxiv   +9 more sources

Cell Cycle Commitment and the Origins of Cell Cycle Variability [PDF]

Frontiers in Cell and Developmental Biology, 2021
Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a ...
Robert F. Brooks, Robert F. Brooks
openaire   +9 more sources

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
R. Kumari, P. Jat
semanticscholar   +1 more source

Copper induces cell death by targeting lipoylated TCA cycle proteins

Science, 2022
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov, S. Coy, Boryana Petrova, Margaret B. Dreishpoon, A. Verma, M. Abdusamad, J. Rossen, Lena M Joesch-Cohen, Ranad Humeidi, R. Spangler, J. Eaton, Evgeni M. Frenkel, M. Kocak, S. M. Corsello, S. Lutsenko, Naama Kanarek, S. Santagata, T. Golub   +17 more
semanticscholar   +1 more source

Cell cycle regulation: p53-p21-RB signaling

Cell Death and Differentiation, 2022
The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
semanticscholar   +1 more source

The Cell Cycle [PDF]

The Oncologist, 2000
The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
Esther D. Israels, L.G. Israels
openaire   +4 more sources

The cell cycle [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
‘Dividing cells pass through a regular sequence of cell growth and division, known as the cell cycle’, according to a college textbook of biology published in 1983 [[1][1]], 5 years before the underlying principles of control were first laid bare during 1988, the annus mirabilis of cell ...
Hunt, T, Nasmyth, K, Novák, B
openaire   +2 more sources

The Influence of Cell Cycle Regulation on Chemotherapy

International Journal of Molecular Sciences, 2021
Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair.
Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu
semanticscholar   +1 more source

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development

Epigenetics & Chromatin, 2022
Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza   +5 more
doaj   +1 more source