Results 11 to 20 of about 15,811,009 (408)
Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov +17 more
semanticscholar +1 more source
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
R. Kumari, P. Jat
semanticscholar +1 more source
Cell cycle regulation: p53-p21-RB signaling
Cell Death and Differentiation, 2022 The retinoblastoma protein RB and the transcription factor p53 are central tumor suppressors. They are often found inactivated in various tumor types. Both proteins play central roles in regulating the cell division cycle. RB forms complexes with the E2F
K. Engeland
semanticscholar +1 more source
Тенденции развития науки и образования, 2023 The cell cycle is part of a general complex of processes that include ensuring the stability of the genetic material. If the cell cycle is disturbed, DNA synthesis is delayed, mitosis does not begin until the completion of replication, and is blocked in ...
Y.V. Kornitskaya +2 more
semanticscholar +1 more source
The Influence of Cell Cycle Regulation on Chemotherapy
International Journal of Molecular Sciences, 2021 Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair.
Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu
semanticscholar +1 more source
Science, 1989 I review recent advances in our knowledge of the eucaryotic cell cycle: the set of processes by which cells grow and divide. Genetic approaches to the cell cycle of somatic cells identified a pathway of events where the initiation of each event was dependent on the successful completion of the preceding event, as well as a single key gene, cdc2 , that ...
openaire +6 more sources
miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells
BMC Cancer, 2022 MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by ...
Garima Singh +2 more
doaj +1 more source
Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila
Nature Communications, 2022 The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear.
Pénélope Darnat +6 more
doaj +1 more source
Cell cycle-dependent expression of Kv3.4 channels modulates proliferation of human uterine artery smooth muscle cells [PDF]
, 2010 Producción CientíficaAims: Vascular smooth muscle cell (VSMC) proliferation is involved in cardiovascular pathologies associated with unwanted arterial wall remodelling.
Cidad Velasco, María del Pilar +6 more
core +1 more source
Molecular Biology of the Cell, 1998 We sought to create a comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle. To this end, we used DNA microarrays and samples from yeast cultures synchronized by three independent methods: alpha factor ...
P. Spellman +8 more
semanticscholar +1 more source