Results 11 to 20 of about 16,339,920 (405)
Cell Cycle Commitment and the Origins of Cell Cycle Variability [PDF]
Frontiers in Cell and Developmental Biology, 2021 Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a ...
Robert F. Brooks, Robert F. Brooks
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The Oncologist, 2000 The Oncologist 2000;5:510-513 www.TheOncologist.com Correspondence: L.G. Israels, M.D., Manitoba Institute of Cell Biology, University of Manitoba, 100 Olivia Street, Winnipeg, Manitoba, Canada, R3E 0V9. Telephone: 204-787-2246; Fax: 204-787-1345; e-mail: lisraels@cc.umanitoba.ca Received August 22, 2000; accepted for publication August 22, 2000 ...
Esther D. Israels, L.G. Israels
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Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 ‘Dividing cells pass through a regular sequence of cell growth and division, known as the cell cycle’, according to a college textbook of biology published in 1983 [[1][1]], 5 years before the underlying principles of control were first laid bare during 1988, the annus mirabilis of cell ...
Hunt, T, Nasmyth, K, Novák, B
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Phasing in on the cell cycle [PDF]
Cell Division, 2018 Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions. Moreover, this discovery has provided a new framework for the study of membrane-less organelle biogenesis and protein ...
Ludo Van Den Bosch +4 more
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The Cell Cycle is a Limit Cycle [PDF]
Mathematical Modelling of Natural Phenomena, 2012 Progression along the successive phases of the mammalian cell cycle is driven by a network of cyclin-dependent kinases (Cdks). This network is regulated by a variety of negative and positive feedback loops. We previously proposed a detailed, 39-variable model for the Cdk network and showed that it is capable of temporal self-organization in the form of
Albert Goldbeter +2 more
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Science, 1989 I review recent advances in our knowledge of the eucaryotic cell cycle: the set of processes by which cells grow and divide. Genetic approaches to the cell cycle of somatic cells identified a pathway of events where the initiation of each event was dependent on the successful completion of the preceding event, as well as a single key gene, cdc2 , that ...
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Cortical Cyclin A controls spindle orientation during asymmetric cell divisions in Drosophila
Nature Communications, 2022 The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear.
Pénélope Darnat +6 more
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Cell cycle and apoptosis [PDF]
Cell Proliferation, 2003 Abstract. Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence both cell division and programmed cell death. The linkage of cell cycle and apoptosis has been recognized for c‐Myc, p53, pRb, Ras, PKA, PKC, Bcl‐2, NF‐κB, CDK, cyclins and CKI. This review summarizes the different functions of the proteins presently
Vermeulen, Katrien +2 more
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miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells
BMC Cancer, 2022 MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by ...
Garima Singh +2 more
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A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology
eLife, 2022 Spatiotemporal mechanisms generating neural diversity are fundamental for understanding neural processes. Here, we investigated how neural diversity arises from neurons coming from identical progenitors.
Jérôme Lacoste +6 more
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