Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S. +4 more
core +4 more sources
Neurogenesis and the Cell Cycle [PDF]
Neuron, 2003 For a long time, it has been understood that neurogenesis is linked to proliferation and thus to the cell cycle. Recently, the gears that mediate this linkage have become accessible to molecular investigation. This review describes some of the progress that has been made in understanding how the molecular machinery of the cell cycle is used in the ...
William A. Harris, Shin-ichi Ohnuma
openaire +3 more sources
ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2020 DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin +10 more
doaj +1 more source
The cell cycle program of polypeptide labeling in Chlamydomonas reinhardtii [PDF]
, 1977 The cell cycle program of polypeptide labeling in syndhronous cultures of wild-type Chlamydomonas reinhardtii was analyzed by pulse-labeling cells with 35SO4 = or [3H]arginine at different cell cycle stages.
Hill, Kim R. +2 more
core +5 more sources
Nature Communications, 2023 Cyclin-dependent kinase (Cdk) stimulates resection of DNA double-strand breaks ends to generate single-stranded DNA (ssDNA) needed for recombinational DNA repair.
Adrián Campos +7 more
doaj +1 more source
Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes [PDF]
, 1994 Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry.
Gull, K, Matthews, K R
core +1 more source
The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
Cancer Cell International, 2020 One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasive, metastatic, drug-resistance, and anti ...
Kai Liu +7 more
semanticscholar +1 more source
IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis
iScience, 2020 Summary: The maintenance of the intestinal epithelium is ensured by the controlled proliferation of intestinal stem cells (ISCs) and differentiation of their progeny into various cell types, including enterocytes (ECs) that both mediate nutrient ...
Alexei Arnaoutov +7 more
doaj +1 more source
Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
BMC Biology, 2022 Background In many organisms, aging is characterized by a loss of mitochondrial homeostasis. Multiple factors such as respiratory metabolism, mitochondrial fusion/fission, or mitophagy have been linked to cell longevity, but the exact impact of each one ...
Montserrat Vega +6 more
doaj +1 more source
Transcriptome changes and cAMP oscillations in an archaeal cell cycle [PDF]
, 2007 Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Baumann, Anke +2 more
core +3 more sources