Results 21 to 30 of about 16,449,484 (363)
ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2020 DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin +10 more
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Journal of Immunology, 1984 The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle.
J. Gerdes +5 more
semanticscholar +1 more source
Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit
Nature Communications, 2016 The activity of the anaphase-promoting complex/cyclosome (APC/C) needs to be regulated in time and space to perform different functions. Here the authors show that Spd2 localizes the APC/C activator Fzr at the centrosomes to promote optimal APC/C ...
Francesco Meghini +6 more
doaj +1 more source
Nature Communications, 2023 Cyclin-dependent kinase (Cdk) stimulates resection of DNA double-strand breaks ends to generate single-stranded DNA (ssDNA) needed for recombinational DNA repair.
Adrián Campos +7 more
doaj +1 more source
The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review
Cancer Cell International, 2020 One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives tumor cells their invasive, metastatic, drug-resistance, and anti ...
Kai Liu +7 more
semanticscholar +1 more source
Conditional control of fluorescent protein degradation by an auxin-dependent nanobody
Nature Communications, 2018 Current approaches to conditionally deplete target proteins require site-specific genetic engineering or have poor temporal control. Here the authors overcome these limitations by combining the AID system with nanobodies to reversibly degrade GFP-tagged ...
Katrin Daniel +5 more
doaj +1 more source
IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis
iScience, 2020 Summary: The maintenance of the intestinal epithelium is ensured by the controlled proliferation of intestinal stem cells (ISCs) and differentiation of their progeny into various cell types, including enterocytes (ECs) that both mediate nutrient ...
Alexei Arnaoutov +7 more
doaj +1 more source
Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging
BMC Biology, 2022 Background In many organisms, aging is characterized by a loss of mitochondrial homeostasis. Multiple factors such as respiratory metabolism, mitochondrial fusion/fission, or mitophagy have been linked to cell longevity, but the exact impact of each one ...
Montserrat Vega +6 more
doaj +1 more source
Nature Communications, 2016 The small molecule (p)ppGpp is commonly produced by bacteria as a signal of nutrient starvation. Here, Ronneau et al. show that (p)ppGpp accumulation in the model bacterium Caulobacter crescentusis modulated by a nitrogen-related phosphotransferase ...
Séverin Ronneau +3 more
doaj +1 more source
Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase
Communicative & Integrative Biology, 2016 Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α ...
François Beaufay +2 more
doaj +1 more source