Results 71 to 80 of about 15,811,009 (408)
Gene Copy Number and Cell Cycle Arrest [PDF]
, 2005 The cell cycle is an orderly sequence of events which ultimately lead to the division of a single cell into two daughter cells. In the case of DNA damage by radiation or chemicals, the damage checkpoints in the $G_{1}$ and $G_{2}$ phases of the cell cycle are activated. This results in an arrest of the cell cycle so that the DNA damage can be repaired.
arxiv +1 more source
Cell cycle: Driving the centrosome cycle [PDF]
Current Biology, 1999 Cyclin-dependent kinases (Cdks) control major transitions as cells pass through the cell cycle. It has recently been shown that centrosome duplication in vertebrates requires Cdk2 activity and can be driven solely by Cdk2-cyclin E complexes.
openaire +3 more sources
The role of the anaphase-promoting complex/cyclosome in plant growth [PDF]
, 2015 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that plays a major role in the progression of the eukaryotic cell cycle.
de Freitas Lima, Marcelo +3 more
core +2 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Self-organization principles of cell cycles and gene expressions in the development of cell populations [PDF]
arXiv, 2021 A big challenge in current biology is to understand the exact self-organization mechanism underlying complex multi-physics coupling developmental processes. With multiscale computations of from subcellular gene expressions to cell population dynamics that is based on first principles, we show that cell cycles can self-organize into periodic stripes in ...
arxiv
A hybrid mammalian cell cycle model [PDF]
EPTCS 125, 2013, pp. 68-83, 2013 Hybrid modeling provides an effective solution to cope with multiple time scales dynamics in systems biology. Among the applications of this method, one of the most important is the cell cycle regulation. The machinery of the cell cycle, leading to cell division and proliferation, combines slow growth, spatio-temporal re-organisation of the cell, and ...
arxiv +1 more source
Single-cell transcriptomes reveal the mechanism for a breast cancer prognostic gene panel. [PDF]
, 2018 The clinical benefits of the MammaPrint® signature for breast cancer is well documented; however, how these genes are related to cell cycle perturbation have not been well determined.
Cai, Jin +10 more
core
DHX33 transcriptionally controls genes involved in the cell cycle [PDF]
, 2016 The RNA helicase DHX33 has been shown to be a critical regulator of cell proliferation and growth. However, the underlying mechanisms behind DHX33 function remain incompletely understood.
Fan, Chunyan +7 more
core +2 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Cell Reports, 2017 Cell cycle kinetics are crucial to cell fate decisions. Although live imaging has provided extensive insights into this relationship at the single-cell level, the limited number of fluorescent markers that can be used in a single experiment has hindered ...
Thomas Zerjatke +8 more
doaj +1 more source