Results 71 to 80 of about 16,449,484 (363)
Nrm1 is a bistable switch connecting cell cycle progression to transcriptional control
EMBO ReportsEntry into the cell cycle requires activation of G1 cyclin-dependent kinases (CDKs) and the G1/S transcriptional program. In fission yeast, the MBF complex is the main transcription factor driving early cell-cycle gene expression.
Guillem Murciano-Julià +12 more
doaj +1 more source
Cell Cycle: Deconstructing Tension [PDF]
Current Biology, 2010 Prior to anaphase, sister chromatids must be attached to microtubules and under tension, a condition that satisfies the spindle checkpoint. Removal of sister chromatid cohesion is predicted to cause a fall in tension. Two studies shed light on how cells avoid re-activation of the spindle checkpoint when cohesion is lost.
openaire +3 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyTrypanosoma cruzi is a protozoan parasite that is the etiological agent of Chagas disease, which is endemic to Latin America with reported cases in non-endemic regions such as Europe, Asia, and Oceania due to migration. During its lifecycle, T.
Bruno Alves Santarossa +7 more
doaj +1 more source
Cell cycle: Driving the centrosome cycle [PDF]
Current Biology, 1999 Cyclin-dependent kinases (Cdks) control major transitions as cells pass through the cell cycle. It has recently been shown that centrosome duplication in vertebrates requires Cdk2 activity and can be driven solely by Cdk2-cyclin E complexes.
openaire +2 more sources
CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest.
Trends in Cell Biology, 2018 Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) have recently entered the therapeutic armamentarium of clinical oncologists, and show promising activity in patients with breast and other cancers.
S. Goel +3 more
semanticscholar +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Cell cycle checkpoint signaling through the ATM and ATR kinases.
Genes & Development, 2001 The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA)
R. Abraham
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source