Results 81 to 90 of about 15,811,009 (408)

Cryptomphalus aspersa Eggs Extract Potentiates Human Epidermal Stem Cell Regeneration and Amplification

Cosmetics, 2021
Modern life and extended life expectancy have prompted the search for natural compounds alleviating skin aging. Evidence supports the beneficial effects on skin integrity and health from the topical administration of preparations of the mollusc ...
Lucía San Juan, Isabel de Pedro, Azahara Rodríguez-Luna, María Villalba, Antonio Guerrero, Salvador González, Alberto Gandarillas   +6 more
doaj   +1 more source

Velde: constructing cell potential landscapes by RNA velocity vector field decomposition [PDF]

arXiv, 2023
The Waddington landscape serves as a metaphor illustrating the developmental process of cells, likening it to a small ball rolling down various trajectories into valleys. Constructing an epigenetic landscape of this nature aids in visualizing and gaining insights into cell differentiation. Development encompasses intricate processes involving both cell
arxiv  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research

Cell Structure and Function
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional biochemical approaches and phosphoproteomics have provided valuable insights into CDK-mediated regulation,
Sachiya Nakashima, Aika Toyama, Hironori Sugiyama, Kazuhiro Aoki, Yuhei Goto   +4 more
doaj   +1 more source

Unbiased Boolean analysis of public gene expression data for cell cycle gene identification. [PDF]

, 2019
Cell proliferation is essential for the development and maintenance of all organisms and is dysregulated in cancer. Using synchronized cells progressing through the cell cycle, pioneering microarray studies defined cell cycle genes based on cyclic ...
Dabydeen, Sarah A, Desai, Arshad, Sahoo, Debashis   +2 more
core   +1 more source

A coupled drug kinetics-cell cycle model to analyse the response of human cells to intervention by topotecan [PDF]

, 2008
A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent topotecan (TPT) is presented. The model includes a novel coupling of both the kinetics of TPT and cell cycle responses to the agent ...
Ali, Reza, Campbell, L., Chappell, M. J. (Michael J.), Errington, Rachel J., Evans, Neil D., Godfrey, Keith, Khan, I. A., Smith, Paul J.   +7 more
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Cell Cycle Assays

, 2023
Creative Bioarray provides Cell Cycle Analysis Service for all of our customers. The cell cycle is the most fundamental and important process by which eukaryotic cells duplicate and divide. The cell cycle consists of two specific and distinct phases: interphase, consisting of G1 (Gap 1), S (synthesis), and G2 (Gap 2), and the mitotic phase; M (mitosis).
openaire   +3 more sources

Deconstructing the cell cycle [PDF]

Nature Reviews Molecular Cell Biology, 2011
When I was an undergraduate student, knowing three key concepts would ensure success in 'Cell Cycle 101': that oscillations of cyclin–cyclin dependent kinase (CDK) complexes drive the cell cycle; that directionality is ensured by the irreversibility of periodic proteasome-mediated cyclin degradation; and that checkpoints ensure the dependence of later ...
openaire   +3 more sources

The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]

, 2016
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa, Bonfanti, Paola, Heimberg, Harry, Heremans, Yves, Leuckx, Gunter, Marazzi, Giovanna, Sassoon, David, Sojoodi, Mozhdeh, Staels, Willem, Stradiot, Leslie, Tanaka, Karo, Van de Casteele, Mark   +11 more
core   +3 more sources