Results 31 to 40 of about 812,761 (308)
Cell cycle checkpoint signaling through the ATM and ATR kinases.
Genes & Development, 2001 The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA)
R. Abraham
semanticscholar +1 more source
Pathways for Genome Integrity in G2 Phase of the Cell Cycle
Biomolecules, 2012 The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen +2 more
doaj +1 more source
Breast Cancer Research, 2022 Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is often ...
Ann Hanna +13 more
doaj +1 more source
Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast
Frontiers in Cell and Developmental Biology, 2021 Symmetry breaking by cellular polarization is an exquisite requirement for the cell-cycle of Saccharomyces cerevisiae cells, as it allows bud emergence and growth.
Martina Galli +7 more
doaj +1 more source
The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death
Microbial Cell, 2016 The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD.
Liselot Dewachter +3 more
doaj +1 more source
Molecular and clinical oncology, 2018 Basic research in genetics, biochemistry and cell biology has identified the executive enzymes and protein kinase activities that regulate the cell division cycle of all eukaryotic organisms, thereby elucidating the importance of site-specific protein ...
E. Gordon +4 more
semanticscholar +1 more source
Vaccinia Virus Arrests and Shifts the Cell Cycle
Viruses, 2022 Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA ...
Caroline K. Martin +6 more
doaj +1 more source
Cell cycle checkpoint control [PDF]
Experimental & Molecular Medicine, 1997 Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects in the cell cycle checkpoint control. Patients of the cancer-prone genetic disorder ataxia telangiectagia frequently develop malignant lymphoma and their cells are ...
Hiroshi Murakami, Hiroto Okayama
openaire +2 more sources
Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]
Proc. Natl. Acad. Sci. 103 16758-16763 (2006), 2006 Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression. This inhibitory signal switches off rapidly once spindle microtubules have attached to all kinetochores.
arxiv +1 more source
A hybrid mammalian cell cycle model [PDF]
EPTCS 125, 2013, pp. 68-83, 2013 Hybrid modeling provides an effective solution to cope with multiple time scales dynamics in systems biology. Among the applications of this method, one of the most important is the cell cycle regulation. The machinery of the cell cycle, leading to cell division and proliferation, combines slow growth, spatio-temporal re-organisation of the cell, and ...
arxiv +1 more source