Results 31 to 40 of about 775,653 (341)

Centrosome-associated regulators of the G₂/M checkpoint as targets for cancer therapy

Molecular Cancer, 2009
In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in response to stress. These regulatory pathways are termed cell-cycle checkpoints.
Broaddus Russell R, Liu Jinsong, Ji Ping, Wang Yingmei, Xue Fengxia, Zhang Wei   +5 more
doaj   +1 more source

Cell cycle checkpoint signaling through the ATM and ATR kinases.

Genes & Development, 2001
The genomes of eukaryotic cells are under continuous assault by environmental agents (e.g., UV light and reactive chemicals) as well as the byproducts of normal intracellular metabolism (e.g., reactive oxygen intermediates and inaccurately replicated DNA)
R. Abraham
semanticscholar   +1 more source

Pathways for Genome Integrity in G2 Phase of the Cell Cycle

Biomolecules, 2012
The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen, Tobias Menzel, Arne Nedergaard Kousholt   +2 more
doaj   +1 more source

Vaccinia Virus Arrests and Shifts the Cell Cycle

Viruses, 2022
Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell DNA ...
Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Mercer   +6 more
doaj   +1 more source

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

Breast Cancer Research, 2022
Aim Deregulated signaling pathways are a hallmark feature of oncogenesis and driver of tumor progression. Dual specificity protein phosphatase 4 (DUSP4) is a critical negative regulator of the mitogen-activated protein kinase (MAPK) pathway and is often ...
Ann Hanna, Mellissa J. Nixon, M. Valeria Estrada, Violeta Sanchez, Quanhu Sheng, Susan R. Opalenik, Abigail L. Toren, Joshua Bauer, Phillip Owens, Frank M. Mason, Rebecca S. Cook, Melinda E. Sanders, Carlos L. Arteaga, Justin M. Balko   +13 more
doaj   +1 more source

The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death

Microbial Cell, 2016
The phenomenon of programmed cell death (PCD), in which cells initiate their own demise, is not restricted to multicellular organisms. Unicellular organisms, both eukaryotes and prokaryotes, also possess pathways that mediate PCD.
Liselot Dewachter, Natalie Verstraeten, Maarten Fauvart, Jan Michiels   +3 more
doaj   +1 more source

Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad-spectrum cancer gene therapy - A review of molecular mechanisms for oncologists

Molecular and clinical oncology, 2018
Basic research in genetics, biochemistry and cell biology has identified the executive enzymes and protein kinase activities that regulate the cell division cycle of all eukaryotic organisms, thereby elucidating the importance of site-specific protein ...
E. Gordon, J. Ravicz, Seiya Liu, S. Chawla, F. Hall   +4 more
semanticscholar   +1 more source

Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast

Frontiers in Cell and Developmental Biology, 2021
Symmetry breaking by cellular polarization is an exquisite requirement for the cell-cycle of Saccharomyces cerevisiae cells, as it allows bud emergence and growth.
Martina Galli, Laura Diani, Roberto Quadri, Alessandro Nespoli, Elena Galati, Davide Panigada, Paolo Plevani, Marco Muzi-Falconi   +7 more
doaj   +1 more source

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. [PDF]

PLoS Biology, 2010
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression.
Genevieve M Vidanes, Frédéric D Sweeney, Sarah Galicia, Stephanie Cheung, John P Doyle, Daniel Durocher, David P Toczyski   +6 more
doaj   +1 more source

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Journal of Immunotherapy for Cancer, 2018
BackgroundNatural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes.
J. Friedman, M. Morisada, Lillian Sun, E. Moore, M. Padget, J. Hodge, J. Schlom, Sofia R. Gameiro, C. Allen   +8 more
semanticscholar   +1 more source