Results 71 to 80 of about 812,761 (308)

tRNA Traffic Meets a Cell-Cycle Checkpoint [PDF]

Cell, 2007
The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression remain largely unresolved. Findings by Ghavidel et al. (2007) reported in this issue suggest that tRNA trafficking and the transcription factor Gcn4 are key intermediates in the process by which yeast cells detect DNA damage and delay cell-cycle progression at the ...
Ted Weinert, Anita K. Hopper
openaire   +3 more sources

ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

PLoS ONE, 2014
Objective Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like properties and their role in platinum resistance.
Erhong Meng, A. Mitra, K. Tripathi, M. Finan, J. Scalici, S. McClellan, L. M. da Silva, E. Reed, L. Shevde, Komaraiah Palle, R. Rocconi   +10 more
semanticscholar   +1 more source

Persistence length of chromatin determines origin spacing in Xenopus early-embryo DNA replication: Quantitative comparisons between theory and experiment [PDF]

Cell Cycle 3, 223-229 (2004), 2003
In Xenopus early embryos, replication origins neither require specific DNA sequences nor is there an efficient S/M checkpoint, even though the whole genome (3 billion bases) is completely duplicated within 10-20 minutes. This leads to the"random-completion problem" of DNA replication in embryos, where one needs to find a mechanism that ensures complete,
arxiv   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication

BMC Cell Biology, 2011
Background Cancer cell responses to chemotherapeutic agents vary, and this may reflect different defects in DNA repair, cell-cycle checkpoints, and apoptosis control.
Kobayashi Tamiyo, Sakaue-Sawano Asako, Ohtawa Kenji, Miyawaki Atsushi   +3 more
doaj   +1 more source

The nature of cell-cycle checkpoints: facts and fallacies [PDF]

Journal of Biology, 2009
The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results.
Conly L. Rieder, Alexey Khodjakov
openaire   +3 more sources

Cell cycle checkpoint regulators reach a zillion

Cell Cycle, 2013
Entry into mitosis is regulated by a checkpoint at the boundary between the G2 and M phases of the cell cycle (G2/M). In many organisms, this checkpoint surveys DNA damage and cell size and is controlled by both the activation of mitotic cyclin-dependent
Kimberly M Yasutis, K. Kozminski
semanticscholar   +1 more source

Ab initio phenomenological simulation of the growth of large tumor cell populations [PDF]

, 2007
In a previous paper we have introduced a phenomenological model of cell metabolism and of the cell cycle to simulate the behavior of large tumor cell populations (Chignola R and Milotti E, Phys. Biol. 2 (2005) 8-22). Here we describe a refined and extended version of the model that includes some of the complex interactions between cells and their ...
arxiv   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Coupling of the cell cycle and metabolism in yeast cell-cycle-related oscillations via resource criticality and checkpoint gating

Letters in Biomathematics, 2018
We investigate the possibility that slow metabolic, cell-cycle-related oscillations in yeast and associated temporal clustering of cells within the cell cycle could be due to an interplay between near-critical metabolism and cell cycle checkpoints.
Luke Morgan, Gregory Moses, Todd R. Young   +2 more
doaj   +1 more source