Results 191 to 200 of about 103,273 (243)

A multiplicative behavioral model of DNA replication initiation in cells. [PDF]

Open Life Sci
Rahman T.
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Cell-cycle checkpoints and cancer

Nature, 2004
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical ...
Michael B, Kastan, Jiri, Bartek
openaire   +4 more sources

Cell cycle checkpoints

Current Opinion in Cell Biology, 1994
Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA.
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Cell Cycle Checkpoints

2000
In eukaryotic cells, cell division proceeds through an orderly series of events in which the cellular contents are duplicated, divided, and distributed to daughter cells. This progression through the cell cycle is governed by the sequential activation and inactivation of members of a family of serine/threonine kinases known as the Cdks (cyclin ...
Kristi Chrispell Forbes, Tamar Enoch
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Cell Cycle Checkpoints

2013
In this entry we describe the molecular mechanisms of the cell cycle checkpoints. We focused our attention on the DNA damage checkpoint and on the spindle assembly and spindle positioning checkpoints, controlling chromosome segregation in mitosis.
M. Muzi Falconi, P. Plevani, F. Amara
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CYCLINS AND CELL CYCLE CHECKPOINTS

Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract  The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several ...
D G, Johnson, C L, Walker
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Cell cycle checkpoints in bacteria

Biochimie, 1997
When DNA replication is interrupted in bacteria, a specific inhibitor (SfiA), a component of the SOS system, is synthesised which transiently blocks cell division. This is the prototype, dispensable, cell cycle checkpoint, essential for maximal survival under a particular stress.
S, Autret, A, Levine, I B, Holland, S J, Séror   +3 more
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Cell Cycle Checkpoints as Therapeutic Targets

Journal of Mammary Gland Biology and Neoplasia, 1999
Most human breast tumors arise from multiple genetic changes which gradually transform differentiated and growth-limited cells into highly invasive cells that are unresponsive to growth controls. The genetic evolution of normal breast cells into cancer cells is largely determined by the fidelity of DNA replication, repair, and division.
Z A, Stewart, J A, Pietenpol
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DNA damage and cell cycle checkpoints

The FASEB Journal, 1996
DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division.
W K, Kaufmann, R S, Paules
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