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Cell cycle: Checkpoint Pathways
Science's STKE, 1999The checkpoint mechanism by which budding yeast Saccharomyces cerevisiae achieve mitotic arrest in response to DNA damage has been studied by Sanchez et al . In mammalian cells and the fission yeast Saccharomyces pombe , DNA damage causes arrest through inhibitory ...
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Cell cycle: Checkpoint Maintenance
Science Signaling, 1999The once inexplicable actions of 14-3-3 proteins gradually become clearer. Members of this protein family bind to phosphorylated proteins and appear to prevent their movement to the nucleus. Chan et al. made human colorectal cancer cells that lacked expression of a particular 14-3-3 protein, 14-3-3sigma. These cells
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The genetics of cell cycle checkpoints
Current Opinion in Genetics & Development, 1995Checkpoints help in the prevention of genetic damage by giving cells time to repair damaged structures before proceeding in the cell cycle. Genetic analyses in budding and fission yeast have identified a large number of cell cycle checkpoint genes. Several of these encode proteins related to components of other signal transduction pathways, including ...
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Studying Cell Cycle Checkpoints Using Drosophila Cultured Cells
2011Drosophila cell lines are valuable tools to study a number of cellular processes, including DNA damage responses and cell cycle checkpoint control. Using an in vitro system instead of a whole organism has two main advantages: it saves time and simple and effective molecular techniques are available. It has been shown that Drosophila cells, similarly to
Siudeja, Katarzyna +2 more
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Cell-cycle checkpoint kinases: checking in on the cell cycle
Current Opinion in Cell Biology, 2000In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice.
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Cell cycle checkpoints and cell surface damage
BioEssays, 2022Marnie Johansson, Duncan J. Clarke
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Cell Cycle | Cell Cycle: DNA Damage Checkpoints
2021Matthew D. Weitzman +2 more
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