Results 1 to 10 of about 3,883,823 (304)

Expressão de marcadores de proliferação celular e apoptose em carcinoma basocelular Markers expression of cell proliferation and apoptosis in basal cell carcinoma

Anais Brasileiros de Dermatologia, 2009
FUNDAMENTOS: O carcinoma basocelular é o câncer mais comum em humanos. Estudos que utilizam recursos da biologia molecular e genética, associados à histomorfologia, permitem a identificação de fatores de risco no desenvolvimento de lesões mais ...
Marília de Pádua Dornelas Corrêa, Ana Paula Ferreira, Ângela Maria Gollner, Michele Fernandes Rodrigues, Magno Cunha de Souza Guerra   +4 more
doaj   +1 more source

Cell cycle: Checkpoint proteins and kinetochores [PDF]

Current Biology, 1997
Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
openaire   +2 more sources

Bilateral Feedback in Oscillator Model Is Required to Explain the Coupling Dynamics of Hes1 with the Cell Cycle

Mathematics, 2022
Biological processes are governed by the expression of proteins, and for some proteins, their level of expression can fluctuate periodically over time (i.e., they oscillate).
Andrew Rowntree, Nitin Sabherwal, Nancy Papalopulu   +2 more
doaj   +1 more source

Endothelin-1 Activates MAPKs and Modulates Cell Cycle Proteins in OKP Cells

Journal of the Formosan Medical Association, 2007
The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown. Methods: These mechanisms were explored using ETB-overexpressing opossum kidney (OKP) cells as a model system. Results: ET-1
Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh   +3 more
doaj   +1 more source

Pocket proteins and cell cycle control [PDF]

Oncogene, 2005
The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket protein' family of cell cycle regulators. These proteins are best known for their roles in restraining the G1-S transition through the regulation of E2F-responsive genes.
openaire   +2 more sources

Cell‐Cycle position and nuclear protein content [PDF]

Cytometry, 1982
AbstractTo determine the change in nuclear protein content as a function of cell cycle position, isolated heLa nuclei were stained for protein with fluorescein isothiocyanate (FITC) and for DNA with propidium iodide (PI) and analyzed by flow cytometry (FCM).
J L, Roti Roti, R, Higashikubo, O C, Blair, N, Uygur   +3 more
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Growth Arrest Triggers Extra-Cell Cycle Regulatory Function in Neurons: Possible Involvement of p27kip1 in Membrane Trafficking as Well as Cytoskeletal Regulation

Frontiers in Cell and Developmental Biology, 2019
Cell cycle regulation is essential for the development of multicellular organisms, but many cells in adulthood, including neurons, exit from cell cycle. Although cell cycle-related proteins are suppressed after cell cycle exit in general, recent studies ...
Takeshi Kawauchi, Takeshi Kawauchi, Yo-ichi Nabeshima   +2 more
doaj   +1 more source

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

eLife, 2021
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation, and
Taylor P Enrico, Wayne Stallaert, Elizaveta T Wick, Peter Ngoi, Xianxi Wang, Seth M Rubin, Nicholas G Brown, Jeremy E Purvis, Michael J Emanuele   +8 more
doaj   +1 more source

PIN1 in Cell Cycle Control and Cancer

Frontiers in Pharmacology, 2018
Cell cycle progression is tightly controlled by many cell cycle-regulatory proteins that are in turn regulated by a family of cyclin-dependent kinases (CDKs) through protein phosphorylation. The peptidyl-prolyl cis/trans isomerase PIN1 provides a further
Chi-Wai Cheng, Eric Tse
doaj   +1 more source

Chromosome Segregation Proteins as Coordinators of Cell Cycle in Response to Environmental Conditions

Frontiers in Microbiology, 2020
Chromosome segregation is a crucial stage of the cell cycle. In general, proteins involved in this process are DNA-binding proteins, and in most bacteria, ParA and ParB are the main players; however, some bacteria manage this process by employing other ...
Monika Pióro, Dagmara Jakimowicz
doaj   +1 more source