Results 51 to 60 of about 3,307,555 (359)

Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]

, 2008
A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González, Chittaranjan, Suganthi, Gorski, Sharon M., Hou, Ying-Chen Claire, McCall, Kimberly   +4 more
core   +4 more sources

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Nature Communications, 2016
Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde, Subbareddy Maddika   +1 more
doaj   +1 more source

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. [PDF]

, 2012
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
A. Antinori, A. Antoniadou, A. Castagna, A. Castagna, A. Cozzi-Lepri, A. D’, A. Mocroft, A. Mocroft, A. Mocroft, A. Noguera-Julian, A. Phillips, A. Rauch, A. Scherrer, B. Gazzard, B. Ledergerber, C. Colin, C. Leport, C. Lewden, C. Mussini, C. Mussini, C. Sabin, C. Sabin, C. Smit, C. Stephan, C. Stephan, C. Thorne, C. Thorne, C. Torti, C. Torti, C. Torti, D. Costagliola, D. Gibb, D. Haerry, E. Girardi, F. Dabis, F. de Wolf, F. Engsig, F. Gutierrez, F. Raffi, G. Chene, G. Fatkenheuer, G. Touloumi, H. Bucher, H. Bucher, H. Bucher, H. Furrer, H. Furrer, H. Furrer, I. Weller, J. Bohlius, J. Casabona, J. Casabona, J. Del Amo, J. Ghosn, J. Ghosn, J. Grarup, J. Kjaer, J. Miro, J. Munoz, J. Ramos, J. Reekie, J. Sterne, J. Warszawski, J.M. Miro, L. Galli, L. Meyer, L. Meyer, L. Meyer, L. Wittkop, M. Battegay, M. Battegay, M. Dorrucci, M. Egger, M. Fisher, M. Garrido, M. Paulsen, M. Prins, M. Prins, M. Psichogiou, M. Puoti, M. Sharland, M. Sharland, M.M. Krause, N. Brockmeyer, N. Obel, N. Obel, N. Obel, O. Kirk, O. Kirk, O. Kirk, O. Kirk, O. Lambotte, P. Morlat, P. Reiss, P. Reiss, P. Reiss, P. Tookey, R. Lodwick, R. Paredes, R. Teira, R. Thiebaut, R. Zangerle, R. Zangerle, R.Teira, S. Ayayi, S. De Wit, S. Grabar, S. Matheron, S. Perez-Hoyos, T. Goetghebuer, V. Bouteloup, V. Le Moing, V. von Wyl, Y. Young   +113 more
core   +6 more sources

A 3D cell death assay to quantitatively determine ferroptosis in spheroids [PDF]

, 2020
The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Declercq, Heidi, Demuynck, Robin, Efimova, Iuliia, Krysko, Dmitri, Lin, Abraham   +4 more
core   +1 more source

Complement the cell death [PDF]

Cell Death & Disease, 2016
10.1038/cddis.2016.369 ; Cell Death and Disease ; 7 ; 11 ...
Yeo, J.G, Leong, J, Lu, J
openaire   +3 more sources

Infection Models for Pine Wilt Disease on the Basis of Vector Behaviors

Population Ecology, EarlyView.
Infection models for pine wilt disease without vector density were built to estimate the transmission coefficient of the pathogenic nematode. The models successfully simulated the annual change in the density of infected trees for four pine stands. ABSTRACT Pine wilt disease is caused by the pinewood nematode (Bursaphelenchus xylophilus Steiner et ...
Katsumi Togashi
wiley   +1 more source

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia. [PDF]

, 2017
BackgroundThe CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL.
Amaya-Chanaga, Carlos I, Amine, Ale-Ali, Castro, Januario E, Choi, Michael Y, Fantin, Valeria R, Gu, Yin, Hallin, Max, Huser, Nanni, Kashyap, Manoj K, Kipps, Thomas J, Kumar, Deepak, Lindquist, Kevin, Liu, Shu-Hui, Pernasetti, Flavia, Rassenti, Laura Z, Simmons, Brett, Smeal, Tod, Yafawi, Rolla, Zhang, Cathy   +18 more
core   +4 more sources

Cell death

Cell
Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating infected cells. Cell death can be induced by the genetically programmed suicide mechanisms of apoptosis, necroptosis, and pyroptosis, or it can be a consequence of dysregulated ...
Kim Newton, Andreas Strasser, Nobuhiko Kayagaki, Vishva M. Dixit   +3 more
openaire   +3 more sources

Cell death by cornification

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed cell death known as cornification. Cornification leads to the formation of the outermost skin barrier, i.e. the cornified layer, as well as to the formation of hair and nails.
Erwin Tschachler, Wim Declercq, Leopold Eckhart, Saskia Lippens   +3 more
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source