Results 1 to 10 of about 243,205 (122)
Criticality in Cell Differentiation [PDF]
arXiv, 2016 Cell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components. Several theoretical studies suggest that cell differentiation is a bifurcation phenomenon,
Bose, Indrani, Pal, Mainak
arxiv +7 more sources
Canadian Respiratory Journal, 2022 Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and progressive interstitial lung disease characterized by recurrent alveolar epithelial cell injury, fibroblast hyperproliferation, and cumulative deposition of extracellular matrix leading
Lan Wang +7 more
doaj +1 more source
Overview of CircRNAs Roles and Mechanisms in Liver Fibrosis
Biomolecules, 2023 Liver fibrosis represents the reversible pathological process with the feature of the over-accumulation of extracellular matrix (ECM) proteins within the liver, which results in the deposition of fibrotic tissues and liver dysfunction. Circular noncoding
Gaiping Wang +6 more
doaj +1 more source
Cell cycle: To differentiate or not to differentiate? [PDF]
Current Biology, 2000 Developmental regulation of the cell cycle is an important determinant of tissue size and shape. Equally important is regulated withdrawal from the cell cycle to allow cells to differentiate. Recent evidence supports a direct link between transcriptional regulation of the cell cycle machinery and cell differentiation.
Robert J. Duronio, Denise L. Myster
openaire +2 more sources
Mitochondrial Dysfunction and Chronic Liver Disease
Current Issues in Molecular Biology, 2022 Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions,
Chunyan Zhang +5 more
doaj +1 more source
Animal Cells and Systems, 2020 Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this ...
Zobia Umair +9 more
doaj +1 more source
Cancer Biology & Therapy, 2023 The possible anticancer activity of combination (M + E + F) of metformin (M), efavirenz (E), and fluoxetine (F) was investigated in normal HDF cells and HCT116 human colon cancer cells.
Beom-Goo Kang +13 more
doaj +1 more source
Scientific Reports, 2023 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine disrupting chemicals (EDCs) are active substances that interfere with hormonal signaling. Among EDCs,
Andrea Di Credico +6 more
doaj +1 more source
DNA methylation dynamics in the rat EGF gene promoter after partial hepatectomy
Genetics and Molecular Biology, 2014 Epidermal growth factor (EGF), a multifunctional growth factor, is a regulator in a wide variety of physiological processes. EGF plays an important role in the regulation of liver regeneration.
Deming Li +3 more
doaj +1 more source
Delayed Liver Regeneration after Partial Hepatectomy in Aged Nos2 Knockout Mice
Cell Journal, 2017 Objective Patients over 60 years of age have higher mortality and morbidity after major liver resections. Nitric oxide (NO) derived from the catalytic activity of Nos2 plays a beneficial role in liver regeneration (LR) after partial hepatectomy (PH). In
Deming Li +6 more
doaj +1 more source