Results 11 to 20 of about 2,690,374 (356)

Criticality in Cell Differentiation [PDF]

Journal of Biosciences, 2016
AbstractCell differentiation is an important process in living organisms. Differentiation is mostly based on binary decisions with the progenitor cells choosing between two specific lineages. The differentiation dynamics have both deterministic and stochastic components.
Bose, Indrani, Pal, Mainak
openaire   +3 more sources

Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment

Nature Communications, 2022
Limited response to immune checkpoint inhibitors has been reported in patients with castration-resistant prostate cancer. Here the authors show that intermittent, but not continuous, treatment with an anti-PI3Kα/β/δ-inhibitor promotes anti-tumor immunity
Zhi Qi, Zihan Xu, Liuzhen Zhang, Yongkang Zou, Jinping Li, Wenyu Yan, Cheng Li, Ningshu Liu, Hong Wu   +8 more
doaj   +1 more source

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. [PDF]

, 2020
Developmental progression depends on temporally defined changes in gene expression mediated by transient exposure of lineage intermediates to signals in the progenitor niche.
Benner, Christopher W, Geusz, Ryan J, Harrington, Austin R, Jhala, Ulupi S, Matta, Ileana, Patel, Nisha A, Rosenfeld, Michael G, Sander, Maike, Shih, Hung-Ping, Vinckier, Nicholas K, Wang, Allen, Wang, Jianxun, Wang, Jinzhao, Wetton, Nichole, Wortham, Matthew   +14 more
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Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies

Stem Cell Research, 2014
Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency.
Josué Kunjom Mfopou, Marloes Geeraerts, Roba Dejene, Stijn Van Langenhoven, Asma Aberkane, Leo A. Van Grunsven, Luc Bouwens   +6 more
doaj   +1 more source

Compositions comprising citrate and applications thereof [PDF]

, 2016
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a ...
Yang, Jian
core   +1 more source

Cell cycle length, cell size, and proliferation rate in hydra stem cells [PDF]

, 1990
We have analyzed the cell cycle parameters of interstitial cells in Hydra oligactis. Three subpopulations of cells with short, medium, and long cell cycles were identified. Short-cycle cells are stem cells; medium-cycle cells are precursors to nematocyte
Bode, Bode, Bode, Bosch, Bosch, Campbell, Charles N. David, David, David, David, David, David, David, David, David, Diehl, Fantes, Fantes, Hobmayer, Holstein, James, Johnston, Leeman, Littlefield, Littlefield, Nurse, Oi, Pardee, Prescott, Rubin, Schmidt, Sproull, Sugiyama, Thomas W. Holstein, Yaross   +34 more
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Helper T cell differentiation [PDF]

Cellular & Molecular Immunology, 2019
CD4+ T helper cells are key regulators of host health and disease. In the original model, specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs, but recent studies have revealed increasing complexities for CD4+ T-cell differentiation. Here, we first discuss CD4+ T-cell
Jordy Saravia, Nicole M. Chapman, Hongbo Chi   +2 more
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In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Stem Cell Reports, 2017
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu, Mio Iwasaki, Hitomi Takakubo, Takumi Sakamoto, Takeshi Ikuno, Mami Miyoshi, Takayuki Kondo, Yoichi Nakao, Masato Nakagawa, Haruhisa Inoue, Jun K. Yamashita   +10 more
doaj   +1 more source

Multi-scale engineering for neuronal cell growth and differentiation [PDF]

, 2011
In this paper we investigate the role of micropatterning and molecular coating for cell culture and differentiation of neuronal cells (Neuro2a cell line) on a polydimethylsiloxane substrate.
Béduer, Amélie, Flahaut, Emmanuel, Loubinoux, Isabelle, Seichepine, Florent, Vaysse, Laurence, Vieu, Christophe   +5 more
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NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

Nature Communications, 2021
Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang, Chuanmao Zhang   +7 more
doaj   +1 more source