Stem Cell Reports, 2017 The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu +10 more
doaj +1 more source
NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation
Nature Communications, 2021 Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Mengjie Sun +7 more
doaj +1 more source
Cell cycle length, cell size, and proliferation rate in hydra stem cells [PDF]
, 1990 We have analyzed the cell cycle parameters of interstitial cells in Hydra oligactis. Three subpopulations of cells with short, medium, and long cell cycles were identified. Short-cycle cells are stem cells; medium-cycle cells are precursors to nematocyte
Bode +34 more
core +1 more source
Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate. [PDF]
, 2017 Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool.
Burrous, Haley +4 more
core +2 more sources
Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease
BMC Genomics, 2018 Background Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth.
Guoliang Lyu +11 more
doaj +1 more source
Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression
Scientific Reports, 2023 Liver fibrosis is caused by chronic hepatic injury and may lead to cirrhosis, and even hepatocellular carcinoma. When hepatic stellate cells (HSCs) are activated by liver injury, they transdifferentiate into myofibroblasts, which secrete extracellular ...
Bingyu Ye +8 more
doaj +1 more source
The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. [PDF]
, 2019 Metabolic reprogramming is an active regulator of stem cell fate choices, and successful stem cell differentiation in different compartments requires the induction of oxidative phosphorylation.
Cunningham, Thomas J +9 more
core +3 more sources
High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters
Biomolecules, 2023 Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition.
Juntang Yang +4 more
doaj +1 more source
Extracellular vesicle-induced differentiation of neural stem progenitor cells [PDF]
, 2019 Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal or glial phenotypes or both.
Biagioni, S. +5 more
core +1 more source
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Nature Communications, 2017 Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response ...
Masahide Kawatou +6 more
doaj +1 more source