Results 21 to 30 of about 12,907,435 (362)

NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation

Nature Communications, 2021
Mitotic spindle assembly is required for proper cell division, but many underlying mechanisms remain unclear. Here, the authors show that NuMa undergoes liquid-liquid phase separation, condensing on spindle poles during mitotic entry and enriching ...
Mengjie Sun, Mingkang Jia, He Ren, Biying Yang, Wangfei Chi, Guangwei Xin, Qing Jiang, Chuanmao Zhang   +7 more
doaj   +1 more source

TOX is a critical regulator of tumour-specific T cell differentiation

Nature, 2019
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states1–6. Here we identify the nuclear factor TOX as a crucial regulator of the differentiation of tumour-specific T (TST ...
A. Scott, F. Dündar, P. Zumbo, Smita S Chandran, C. Klebanoff, M. Shakiba, Prerak M. Trivedi, Laura Menocal, H. Appleby, Steven Camara, D. Zamarin, T. Walther, A. Snyder, Matthew R Femia, E. Comen, H. Wen, M. Hellmann, N. Anandasabapathy, Yong Liu, N. Altorki, P. Lauer, Olivier Levy, M. Glickman, J. Kaye, D. Betel, M. Philip, A. Schietinger   +26 more
semanticscholar   +1 more source

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Stem Cell Reports, 2017
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu, Mio Iwasaki, Hitomi Takakubo, Takumi Sakamoto, Takeshi Ikuno, Mami Miyoshi, Takayuki Kondo, Yoichi Nakao, Masato Nakagawa, Haruhisa Inoue, Jun K. Yamashita   +10 more
doaj   +1 more source

Role of PDLIM1 in hepatic stellate cell activation and liver fibrosis progression

Scientific Reports, 2023
Liver fibrosis is caused by chronic hepatic injury and may lead to cirrhosis, and even hepatocellular carcinoma. When hepatic stellate cells (HSCs) are activated by liver injury, they transdifferentiate into myofibroblasts, which secrete extracellular ...
Bingyu Ye, Mengli Yu, Meijuan Yue, Man Yin, Chunyan Zhang, Qiwen Wang, Xinru Ding, Wenlong Shen, Zhihu Zhao   +8 more
doaj   +1 more source

High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters

Biomolecules, 2023
Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the pulmonary parenchyma caused by excessive extracellular matrix deposition.
Juntang Yang, Chenxi Liang, Lulu Liu, Lan Wang, Guoying Yu   +4 more
doaj   +1 more source

Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease

BMC Genomics, 2018
Background Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth.
Guoliang Lyu, Chao Zhang, Te Ling, Rui Liu, Le Zong, Yiting Guan, Xiaoke Huang, Lei Sun, Lijun Zhang, Cheng Li, Yu Nie, Wei Tao   +11 more
doaj   +1 more source

Chromatin architecture reorganization during stem cell differentiation

Nature, 2015
Higher-order chromatin structure is emerging as an important regulator of gene expression. Although dynamic chromatin structures have been identified in the genome, the full scope of chromatin dynamics during mammalian development and lineage ...
Jesse R. Dixon, Inkyung Jung, Siddarth Selvaraj, Yin Shen, Jessica Antosiewicz-Bourget, Ah Young Lee, Z. Ye, Audrey Kim, N. Rajagopal, Wei Xie, Yarui Diao, Jing Liang, Huimin Zhao, Victor V Lobanenkov, J. Ecker, J. Thomson, B. Ren   +16 more
semanticscholar   +1 more source

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Nature Communications, 2017
Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response ...
Masahide Kawatou, Hidetoshi Masumoto, Hiroyuki Fukushima, Gaku Morinaga, Ryuzo Sakata, Takashi Ashihara, Jun K. Yamashita   +6 more
doaj   +1 more source

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse

Scientific Reports, 2018
The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start ...
Valérie Bégay, Christian Baumeier, Karin Zimmermann, Arnd Heuser, Achim Leutz   +4 more
doaj   +1 more source

Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel

Nature, 2018
Somatic stem cells constantly adjust their self-renewal and lineage commitment by integrating various environmental cues to maintain tissue homeostasis.
Li He, Guangwei Si, Jiuhong Huang, Aravinthan D. T. Samuel, N. Perrimon   +4 more
semanticscholar   +1 more source