Results 81 to 90 of about 5,163,880 (297)

A novel binary particle fractionation technique

, 2010
An interesting development towards a robust particle fractionator is presented. Typically acoustic fractionators rely on time of flight in a constant acoustic field to separate different populations .
Harris, Nick, Hill, Martyn, Glynne-Jones, Peter, Boltryk, Rosemary   +3 more
core  

Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models [PDF]

, 2013
Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon.
ALLENA, Rachele
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Protocol for the isolation and purification of endoplasmic reticulum-plasma membrane junctions from the mouse brain

STAR Protocols
Summary: Dynamic communication between intracellular organelles often takes place at specialized membrane contact sites that form between their membranes.
Jason A. Weesner, Diantha van de Vlekkert, Leigh Ellen Fremuth, Alessandra d’Azzo   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The Combination of Temporal and Spatial Dose Fractionation in Microbeam Radiation Therapy

Biomedicines
Background: Microbeam radiation therapy (MRT) is an advanced preclinical approach in radiotherapy that utilizes spatially fractionated dose distributions by collimating x-rays into micrometer-wide, planar beams.
Jessica Stolz, Kristina Rogal, Sandra Bicher, Johanna Winter, Mabroor Ahmed, Susanne Raulefs, Stephanie E. Combs, Stefan H. Bartzsch, Thomas E. Schmid   +8 more
doaj   +1 more source

Cell fractionation and proteomic strategy analyses.

, 2018
Cell fractionation and proteomic strategy analyses.
Arthur Henriques Pontes (5843666), Carlos André Ornelas Ricart (797488), Beatriz Dolabela de Lima (797487), Agenor de Castro Moreira dos Santos Júnior (797482), Agnelo Rodrigues de Souza (5843669), Mariana Souza Castro (4181482), Marcelo Valle de Sousa (797486), Wagner Fontes (573686)   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Silicon isotope fractionation during silica precipitation from aqueous solutions: Experimental and field evidence [PDF]

, 2013
Climate conditions during Earth’s earliest history were very different from today. Knowledge about this issue is crucial for understanding the development of life on our planet.
Petrology, NWO-ALW Open: Exploring the Earth's earliest oceans with silicon: magnitudes of isotopic fractionation, Geilert, S.   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source