Results 1 to 10 of about 3,826,181 (348)
A pan-cancer survey of cell line tumor similarity by feature-weighted molecular profiles. [PDF]
Cell Rep Methods, 2021 Summary Patient-derived cell lines are often used in pre-clinical cancer research, but some cell lines are too different from tumors to be good models.
Sinha R, Luna A, Schultz N, Sander C.
europepmc +2 more sources
Storage conditions and passages alter IL-6 secretion in C26 adenocarcinoma cell lines [PDF]
MethodsX, 2015 The C26 adenocarcinoma tumor line is frequently used to establish peripheral tumors in mice for the study of cancer cachexia and cancer-related fatigue. Recently, we have noticed a progressive decline in the effects of tumor growth on our biological and ...
Diana M. Norden +3 more
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Global computational alignment of tumor and cell line transcriptional profiles
Nature Communications, 2021 The determination of whether cancer cell lines recapitulate the molecular features of corresponding patient tumours remains essential for the selection of appropriate cell line models for preclinical studies.
Allison Warren +8 more
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Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines [PDF]
Frontiers in Pharmacology, 2015 Yessotoxin (YTX) modulates cellular phosphodiesterases (PDEs). In this regard, opposite effects had been described in the tumor model K-562 cell line and fresh human lymphocytes in terms of cell viability, cyclic adenosine 3´,5´-cyclic monophosphate ...
Andrea Fernández Araújo +4 more
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Establishment and Characterization of MCA23, a Novel Mouse Intrahepatic Cholangiocarcinoma Cell Line [PDF]
Cancer MedicineIntroduction Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of malignancy. Recent advancements have highlighted the importance of the tumor immune microenvironment in therapeutic responses and prognosis.
Yuchao He +12 more
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Cancer Cell International, 2021 Background Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), play a crucial role in cancer ...
Yuanyuan Li, Ling Gu
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Role of crocin in several cancer cell lines: An updated review [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Cancer is a major public health problem worldwide. The most important considerable features of cancer cells are uncontrolled proliferation, up-regulated differentiation, and immortality.
Ali Veisi +5 more
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Establishment and characterization of a canine chondrosarcoma cell line: Mango
Animal Diseases, 2023 In the global progress of bone tumor research, established stable and long-lasting transgenic chondrosarcoma (CSA) cell lines are rare, mainly of murine and human origin, while the establishment of canine CSA cell lines has yet to be reported. This study
Meilin Wang +10 more
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bioRxiv, 2020 In cancer research and drug development, human tumor-derived cell lines are used as popular model for cancer patients to evaluate the biological functions of genes, drug efficacy, side-effects, and drug metabolism.
Banabithi Bose, S. Bozdag
semanticscholar +1 more source
The Curious Case of the HepG2 Cell Line: 40 Years of Expertise
International Journal of Molecular Sciences, 2021 Liver cancer is the third leading cause of cancer death worldwide. Representing such a dramatic impact on our lives, liver cancer is a significant public health concern.
V. Arzumanian +2 more
semanticscholar +1 more source