Results 11 to 20 of about 3,494,106 (354)
Global computational alignment of tumor and cell line transcriptional profiles
Nature Communications, 2021 The determination of whether cancer cell lines recapitulate the molecular features of corresponding patient tumours remains essential for the selection of appropriate cell line models for preclinical studies.
Allison Warren +8 more
doaj +2 more sources
Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. [PDF]
PLoS ONE, 2013 Pheochromocytomas are rare tumors generally arising in the medullary region of the adrenal gland. These tumors release excessive epinephrine and norepinephrine resulting in hypertension and cardiovascular crises for which surgery is the only definitive ...
Hans K Ghayee +17 more
doaj +2 more sources
A pan-cancer survey of cell line tumor similarity by feature-weighted molecular profiles. [PDF]
Cell Rep Methods, 2021 Sinha R, Luna A, Schultz N, Sander C.
europepmc +2 more sources
Disconnected circadian and cell cycles in a tumor-driven cell line
Communicative & Integrative Biology, 2010 Cell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled ...
Julie S. Pendergast +4 more
doaj +3 more sources
Predicting tumor cell line response to drug pairs with deep learning
BMC Bioinformatics, 2018 Background The National Cancer Institute drug pair screening effort against 60 well-characterized human tumor cell lines (NCI-60) presents an unprecedented resource for modeling combinational drug activity.
Fangfang Xia +11 more
doaj +2 more sources
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. [PDF]
Nature Communications, 2019 Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors.
Aran, D +9 more
core +3 more sources
Biophysical Profiling of Tumor Cell Lines [PDF]
Analytical Cellular Pathology, 2011 Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. The Corning Epic® optical biosensor was used to monitor dynamic mass rearrangements within and proximal to the cell membrane in tumor cell lines derived from cancers of the ...
Rachid Hamid +4 more
openaire +4 more sources
bioRxiv, 2020 In cancer research and drug development, human tumor-derived cell lines are used as popular model for cancer patients to evaluate the biological functions of genes, drug efficacy, side-effects, and drug metabolism.
Banabithi Bose, S. Bozdag
semanticscholar +1 more source
The Curious Case of the HepG2 Cell Line: 40 Years of Expertise
International Journal of Molecular Sciences, 2021 Liver cancer is the third leading cause of cancer death worldwide. Representing such a dramatic impact on our lives, liver cancer is a significant public health concern.
V. Arzumanian +2 more
semanticscholar +1 more source
Comparison of the Effects of Fucoidans on the Cell Viability of Tumor and Non-Tumor Cell Lines [PDF]
Marine Drugs, 2019 Fucoidans extracted from brown algae exert manifold biological activities paving the way for the development of numerous applications including treatments outside tumor therapy such as age-related macular degeneration or tissue engineering. In this study, we investigated the antiproliferative effects of fucoidans extracted from six different algae ...
Deniz Tasdemir +7 more
openaire +5 more sources