Results 61 to 70 of about 3,494,106 (354)

Establishment and characterization of a HER2-enriched canine mammary cancerous myoepithelial cell line

BMC Veterinary Research, 2023
Background Canine mammary tumors (CMTs) have a poor prognosis, along with tumor recurrence and metastasis. Cell lines are vital in vitro models for CMT research. Many CMT epithelial cell lines were reported.
Aolei Chen, Shaotang Ye, Jiahui Zheng, Jichao Li, Zejia Chen, Yashan Zhang, Shoujun Li   +6 more
doaj   +1 more source

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]

, 2013
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Bertherat, Jérôme, Beuschlein, Felix, Bonnet, Stéphane, Gaujoux, Sébastien, Guillaud-Bataille, Marine, Hantel, Constanze, Launay, Pierre, Lefèvre, Lucile, Perlemoine, Karine, Ragazzon, Bruno, Rizk-Rabin, Marthe, Tissier, Frédérique   +11 more
core   +3 more sources

A patient‐derived xenograft and a cell line derived from it form a useful preclinical model for small bowel adenocarcinoma

Cancer Medicine, 2020
Basic and clinical studies on small bowel adenocarcinoma (SBA) are limited due to the rare nature of this cancer. We established a patient‐derived xenograft (PDX) model from the tumor tissue of an advanced SBA patient with liver and peritoneal metastasis,
Tomoki Yamano, Shuji Kubo, Naohiro Tomita   +2 more
doaj   +1 more source

Establishment of a New Cell Line of Canine Mammary Tumor CMT-1026

Frontiers in Veterinary Science, 2021
Canine mammary tumors (CMTs) have histopathological, epidemiologic and clinical characteristics similar to those in humans and are known to be one of the best models for human breast cancer (HBC).
Chen Mei, Chen Mei, Liang Xin, Yang Liu, Jiabao Lin, Hong Xian, Xue Zhang, Wei Hu, Zhaofei Xia, Hongjun Wang, Yanli Lyu   +10 more
doaj   +1 more source

Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer [PDF]

, 2020
Adoptive T cell based immunotherapy is gaining significant traction in cancer treatment. Despite its limited success, so far, in treating solid cancers, it is increasingly successful, demonstrating to have a broader therapeutic potential. In this paper we develop a mathematical model to study the efficacy of engineered T cell receptor (TCR) T cell ...
arxiv   +1 more source

GSK-3β signaling determines autophagy activation in the breast tumor cell line MCF7 and inclusion formation in the non-tumor cell line MCF10A in response to proteasome inhibition

Cell Death and Disease, 2013
The ubiquitin–proteasome system and the autophagy–lysosome pathway are the two main mechanisms for eukaryotic intracellular protein degradation. Proteasome inhibitors are used for the treatment of some types of cancer, whereas autophagy seems to have a ...
E. Gavilan, E. Gavilan, I. Sánchez-Aguayo, P. Daza, D. Ruano, Diego Ruano   +5 more
semanticscholar   +1 more source

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. [PDF]

, 2014
A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584,
Gruber, Harry E, Hiraoka, Kei, Inagaki, Akihito, Iwamoto, Keisuke S, Jolly, Douglas J, Kamijima, Shuichi, Kasahara, Noriyuki, McBride, William H, Micewicz, Ewa, Robbins, Joan M, Takahashi, Masamichi, Valdes, Gilmer   +11 more
core   +2 more sources

First‐Line Atezolizumab plus Chemotherapy in Extensive‐Stage Small‐Cell Lung Cancer

New England Journal of Medicine, 2018
BACKGROUND Enhancing tumor‐specific T‐cell immunity by inhibiting programmed death ligand 1 (PD‐L1)–programmed death 1 (PD‐1) signaling has shown promise in the treatment of extensive‐stage small‐cell lung cancer.
L. Horn, A. Mansfield, A. Szczesna, L. Havel, M. Krzakowski, M. Hochmair, F. Huemer, G. Losonczy, M. Johnson, M. Nishio, M. Reck, T. Mok, S. Lam, D. Shames, Juan Liu, B. Ding, A. López-Chávez, F. Kabbinavar, W. Lin, A. Sandler, Stephen V. Liu   +20 more
semanticscholar   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Use of high-dosage chemotherapy with autologous hematopoietic stem cell transplantation as a first-line therapy for the patients with poor-prognosis testicular tumors [PDF]

Vojnosanitetski Pregled, 2005
Background. High-dose chemotherapy followed by hematopoietic stem cell support can be used as a first-line treatment in patients with germ-cell tumor (GCT) with poor prognosis. Long-term survival rate is attained in 50% of these patients. The aim of this
Marjanović Slobodan, Cerović Snežana, Brajušković Goran R.   +2 more
doaj   +1 more source