Results 51 to 60 of about 378,972 (309)

Dynamics of membrane lipid domains in neuronal cells differentiated in culture1

Journal of Lipid Research, 2003
Treatment with methyl-β-cyclodextrin (MCD) induced a time- and dose-dependent efflux of cholesterol, sphingolipids, and phosphatidylcholine (PC) from cerebellar neurons differentiated in culture. With a “mild” treatment, the loss of cell lipids induced a
Elena Ottico, Alessandro Prinetti, Simona Prioni, Claudia Giannotta, Luisa Basso, Vanna Chigorno, Sandro Sonnino   +6 more
doaj   +1 more source

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Kepp, Oliver, Meinecke, M., Harsman, Anke, Meinecke, Michael, Joachim Rassow, Hauf, Eva, Kepp, O., Günther, Dirk, Oliver Kepp, Richard Wagner, Dirk Günther, Thomas Rudel, Hauf, E., Wagner, R., Katharina Ross, Rassow, Joachim, Volker Brinkmann, Brinkmann, Volker, Rajalingam, Krishnaraj, Ines Herrmann, Elke A. Dian-Lothrop, Brinkmann, V., Kozjak-Pavlovic, V., Günther, D., Kozjak-Pavlovic, Vera, Ross, Katharina, Eva Hauf, Vera Kozjak-Pavlovic, Michael Meinecke, Robert Hurwitz, Dian-Lothrop, E., Wagner, Richard, Ross, K., Rajalingam, K., Rudel, T., Dian-Lothrop, Elke A., Rudel, Thomas, Hurwitz, Robert, Krishnaraj Rajalingam, Harsman, A., Elke A Dian-Lothrop, Herrmann, I., Hurwitz, R., Herrmann, Ines, Rassow, J., Anke Harsman   +45 more
core   +2 more sources

CO2 Permeability of Biological Membranes and Role of CO2 Channels

Membranes, 2017
We summarize here, mainly for mammalian systems, the present knowledge of (a) the membrane CO2 permeabilities in various tissues; (b) the physiological significance of the value of the CO2 permeability; (c) the mechanisms by which membrane CO2 ...
Volker Endeward, Mariela Arias-Hidalgo, Samer Al-Samir, Gerolf Gros   +3 more
doaj   +1 more source

Femtosecond optoinjection of intact tobacco BY-2 cells using a reconfigurable photoporation platform. [PDF]

PLoS ONE, 2013
A tightly-focused ultrashort pulsed laser beam incident upon a cell membrane has previously been shown to transiently increase cell membrane permeability while maintaining the viability of the cell, a technique known as photoporation.
Claire A Mitchell, Stefan Kalies, Tomás Cizmár, Alexander Heisterkamp, Lesley Torrance, Alison G Roberts, Frank J Gunn-Moore, Kishan Dholakia   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Computational nanoscience and molecular modelling of shock wave interactions with biological membranes [PDF]

, 2011
Lateral diffusion of membrane components (lipids and proteins) is an important membrane property to measure since the essential process of absorption of anti-cancer and other drugs -some of which are not soluble in lipids and therefore would not be ...
Sourmaidou, Damiani
core  

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family [PDF]

, 2009
Background: Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Rodrigues, N.T.L., Maria S Balda, Nelio TL Rodrigues, Matter Karl, Balda Maria S, Karl Matter, Steed, E., Balda, M.S., Matter, K., Steed Emily, Rodrigues Nelio TL, Emily Steed   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Determination of cell membrane permeability in concentrated cell ensembles

Biophysical Journal, 1987
The method of volume averaging is used to analyze the process of diffusion in concentrated cell ensembles in which significant resistance to mass transfer is caused by the cellular membrane. A general closure scheme is given that allows for direct theoretical prediction of effective diffusivities for any cellular geometry.
Ochoa, J.A., Whitaker, S., Stroeve, P.
openaire   +2 more sources