Results 51 to 60 of about 9,017,426 (338)

Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane

Scientific Reports, 2021
Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used molecular dynamics simulations to predict the membrane permeability of natural drugs—withanolides (
Renu Wadhwa, Neetu Singh Yadav, Shashank P. Katiyar, Tomoko Yaguchi, Chohee Lee, Hyomin Ahn, Chae-Ok Yun, Sunil C. Kaul, Durai Sundar   +8 more
doaj   +1 more source

Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin [PDF]

, 2003
Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY.
Dominga Deluca, Schaschke, N., Gil-Parrado, S, Werner M.a.c.h.l.e.i.d.t., Luis Moroder, Dietmar Pfeiler, Irmgard Assfalg Machleidt, Machleidt, Werner, Fiorino, F, Pfeiler, D., Pfeiler, D, Machleidt, W, Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Moroder, L, Deluca, D, Gil-Parrado, S., Moroder, L., Fiorino, F., Assfalg-Machleidt, I, Norbert Schaschke, Deluca, D., FIORINO, FERDINANDO, Shirley Gil Parrado   +23 more
core   +1 more source

The Effect of Low Voltage High Frequency Electric Pulses on The Extracellular Conductivity, Cell Permeability and Time-Depended Manner of MCF7 Cell Line

Journal of Associated Medical Sciences
Background: Low voltage, high frequency electrochemotherapy (LVHF ECT) has recently been explored as a method to enhance the permeability of cell membranes to non-permanent chemotherapeutic agents.
Zeinab Shankayi, S. Mohammad Firoozabadi, Mahmoud ashouri mendi   +2 more
doaj   +1 more source

Identification of senescence and death in Emiliania huxleyi and Thalassiosira pseudonana: Cell staining, chlorophyll alterations, and dimethylsulfoniopropionate (DMSP) metabolism [PDF]

, 2012
We measured membrane permeability, hydrolytic enzyme, and caspase-like activities using fluorescent cell stains to document changes caused by nutrient exhaustion in the coccolithophore Emiliania huxleyi and the diatom Thalassiosira pseudonana, during ...
Berges, John A., Bongaerts, Roy J., Fernandes, Michelle, Berges, JA, Berges, J.A., Malin, G, Bongaerts, R.J., Malin, Gill, Fernandes, M., Malin, G., Airs, R.L., Bell, T.G., Bongaerts, RJ, Airs, Ruth L., Bell, Thomas G., Franklin, Daniel J., Airs, RL, Franklin, D, Fernandes, M, Bell, TG   +19 more
core   +1 more source

Alcohol Diffusion in Alkali-Metal-Doped Polymeric Membranes for Using in Alkaline Direct Alcohol Fuel Cells

Membranes, 2022
The alcohol permeability of anion exchange membranes is a crucial property when they are used as a solid electrolyte in alkaline direct alcohol fuel cells and electrolyzers.
Andrea Fernández-Nieto, Sagrario Muñoz, Vicenta María Barragán   +2 more
doaj   +1 more source

IDEAL-Cell, a High Temperature Innovative Dual mEmbrAne Fuel-Cell [PDF]

, 2009
IDEAL-Cell is a new concept of a high temperature fuel cell operating in the range 600-700°C. It is based on the junction between the anode part of a PCFC and the cathode part of a SOFC through a mixed H+ and O2- conducting porous ceramic membrane.
Stoynov, Z., A. Chesnaud, A. S. Thorel, D. Vladikova, Vladikova, D., BARBUCCI, ANTONIO, Presto, S., M. Viviani, Viviani, M., Chesnaud, A., Z. Stoynov, PICCARDO, PAOLO, S. Presto, Thorel, A.S, Ilhan, Zeynep, Piccardo, P, Z. Ilhan, Barbucci, A., Vladikova D, Stoynov Z, Chesnaud A, Barbucci A, Viviani M, Thorel A, Ilhan Z, Presto S, Piccardo P, Palard, Mickael, Prazuch, J., Caboche, G., Combemale, L., Zdravko Stoynov, Massimo Viviani, Fatome, E., Anthony Chesnaud, Ardigò, M. R., Antonio Barbucci, Daria E. Vladikova, Brylewski, T., Hochepied, Jean-François, Sabrina Presto, Paolo Piccardo, Piccardo, P., Chevalier, S., Przybylski, K., Ruckdäschel, R., Alain S. Thorel, Zeynep Ilhan, Perron, A.   +48 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of aquaporin-lipid molar ratio on the permeability of an aquaporin Z-phospholipid membrane system.

PLoS ONE, 2020
Aquaporins are water-permeable membrane-channel proteins found in biological cell membranes that selectively exclude ions and large molecules and have high water permeability, which makes them promising candidates for water desalination systems.
Hyunki Kim, Byung Ho Lee, Moon-Ki Choi, Sangjae Seo, Moon Ki Kim   +4 more
doaj   +1 more source

Study of the effect of membrane thickness on microcapsule strength, permeability, and cell proliferation

, 2013
Cell microencapsulation is one of the promising strategies for in vitro production of proteins or in vivo delivery of therapeutic products. Membrane thickness controls microcapsule strength and permeability, which may in return affect cell growth and ...
Wang, Qiuyan, Tan, Mingqian, Wang, Yu, 马小军, Ma, Ying, Li, Na, Yu, Weiting, Zhang, Ying, Liu, Yang, Chen, Li, Ma, Xiaojun   +10 more
core   +1 more source