Results 81 to 90 of about 14,513,312 (335)
Cell Adhesion & Migration, 2019 Dysfunction of vascular smooth muscle cells (VSMCs) mediates intracranial aneurysm (IA). KDR is reported to alleviate IA progression via promoting VSMC proliferation, while the upstream regulators are still unclear.
Yushe Wang +6 more
doaj +1 more source
Structure, regulatory factors and cancer-related physiological effects of ADAM9
Cell Adhesion & Migration, 2020 The ADAMs family belongs to the transmembrane protein superfamily of zinc-dependent metalloproteases, which consists of multiple domains. These domains have independent but complementary functions that enable them to participate in multiple biological ...
MA Haoyuan, LI Yanshu
doaj +1 more source
M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer.
Cancer Research, 2018 Clinical and experimental evidence has shown that tumor-associated macrophages promote cancer initiation and progression. However, the macrophage-derived molecular determinants that regulate colorectal cancer metastasis have not been fully characterized.
Jingqin Lan +12 more
semanticscholar +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell Adhesion & Migration, 2019 The anchored fibroblast-populated collagen matrix (aFPCM) is an appropriate model to study fibrocontractive disease mechanisms. Our goal was to determine if aFPCM height reduction (compaction) during development is sufficient to predict tension ...
Melville B. Vaughan +4 more
doaj +1 more source
The multiple faces of leukocyte interstitial migration
, 2014 Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in ...
Germain, R., Lämmermann, T.
core +1 more source
The tumor-promoting functions of Ataxia-telangiectasia mutated (ATM) in cancer cells [PDF]
, 2015 textAtaxia-telangiectasia mutated (ATM) protein kinase regulates the DNA damage response (DDR) and is associated with cancer suppression by protecting cells from DNA double-strand breaks (DSBs). However, how ATM functions outside of DSB signaling is less
Chen, Wei-Ta, active 21st century
core +1 more source
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
Nature Communications, 2018 Studies of cancer cell migration have found two modes: one that is protease-independent, requiring micron-sized pores or channels for cells to squeeze through, and one that is protease-dependent, relevant for confining nanoporous matrices such as ...
Katrina M. Wisdom +10 more
semanticscholar +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Cell Adhesion & Migration, 2021 Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human ...
Yanling Jin +9 more
doaj +1 more source