Results 91 to 100 of about 14,513,312 (335)

In ovo time-lapse analysis after dorsal neural tube ablation shows rerouting of chick hindbrain neural crest [PDF]

, 2000
Previous analyses of single neural crest cell trajectories have suggested important roles for interactions between neural crest cells and the environment, and amongst neural crest cells. To test the relative contribution of intrinsic versus extrinsic
Bronner-Fraser, Marianne, Fraser, Scott, Kulesa, Paul   +2 more
core  

KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment [PDF]

, 2016
Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent ...
Catalano, Myriam, Chece, Giuseppina, D'Alessandro, Giuseppina, Di Angelantonio, Silvia, Esposito, Vincenzo, Esposito, Vincenzo, Grimaldi, Alfonso, Limatola, Cristina, Mainiero, Fabrizio, Porzia, Alessandra, Ragozzino, Davide, Salvati, Maurizio, Santoro, Antonio, Wulff, Heike   +13 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

T lymphocytes migrate upstream after completing the leukocyte adhesion cascade

Cell Adhesion & Migration, 2019
The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions.
Nicholas R. Anderson, Alexander Buffone, Daniel A. Hammer   +2 more
doaj   +1 more source

Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells

Cell Adhesion & Migration, 2021
Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial
Sofia Mogren, Frida Berlin, Sangeetha Ramu, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Cecilia K Andersson   +6 more
doaj   +1 more source

Migration and proliferation dichotomy in tumor cell invasion [PDF]

, 2006
We propose a two-component reaction-transport model for the migration-proliferation dichotomy in the spreading of tumor cells. By using a continuous time random walk (CTRW) we formulate a system of the balance equations for the cancer cells of two ...
A. Iomin, Alexander Iomin, E. W. Montroll, J. D. Murray, M. Freidlin, Sergei Fedotov   +5 more
core   +1 more source

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

Journal of Cell Biology, 2017
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood.
B. Erdogan, Mingfang Ao, L. White, A. Means, Bryson M Brewer, Lijie Yang, M. Washington, Chanjuan Shi, O. Franco, O. Franco, Alissa M. Weaver, Simon W. Hayward, Simon W. Hayward, Deyu Li, D. Webb   +14 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Primordial Germ Cell Migration

The International Journal of Developmental Biology, 1986
Mutational and antisense screens in Drosophila and zebrafish, and transcriptional profiling and time-lapse analysis in the mouse, have contributed greatly to our understanding of PGC development. In all three systems, the behavior of PGCs is controlled by growth factors which signal through G-protein coupled receptors and/or tyrosine kinase receptors ...
C C, Wylie, D, Stott, P J, Donovan
openaire   +6 more sources

Platelet endothelial aggregation receptor-1 regulates bovine muscle satellite cell migration and differentiation via integrin beta-1 and focal adhesion kinase

Cell Adhesion & Migration, 2019
PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3.
Yusheng Pang, Ziheng Zhang, Zhao Wang, Yuxin Wang, Yunqin Yan, Shufeng Li, Huili Tong   +6 more
doaj   +1 more source