Results 91 to 100 of about 347,216 (308)
Morphed and moving: TNFα-driven motility promotes cell dissemination through MAP4K4-induced cytoskeleton remodeling [PDF]
, 2014 Cell dissemination from an initial site of growth is a highly coordinated and controlled process that depends on cell motility. The mechanistic principles that orchestrate cell motility, namely cell shape control, traction and force generation, are ...
Min Ma, Martin Baumgartner
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling cell movement, cell differentiation, cell sorting and proportion regulation in Dictyostelium discoideum aggregations [PDF]
, 2015 Understanding the mechanisms that control tissue morphogenesis and homeostasis is a central goal not only in developmental biology but also has great relevance for our understanding of various diseases, including cancer.
Weijer, C. J.; id_orcid +2 more
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TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells
Life Science AllianceTBXA2R signaling activates ERMs through Gαq/11-Gα12/13, Rho GTPases, and SLK/LOK, boosting TNBC cell migration, invasion, and metastatic colonization. Cell migration and invasion are critical for cancer cell metastasis, relying on the ability of cells to
Kévin Leguay +12 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration [PDF]
, 2019 Ageing is the result of changes in biochemical and biophysical processes at the cellular level that lead to progressive organ decline. Here we focus on the biophysical changes that impair cellular function of human dermal fibroblasts using donors of ...
Sliogeryte, K +3 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
On the influence of cannabinoids on cell morphology and motility of glioblastoma cells.
PLoS ONE, 2019 The mechanisms behind the anti-tumoral effects of cannabinoids by impacting the migratory activity of tumor cells are only partially understood. Previous studies demonstrated that cannabinoids altered the organization of the actin cytoskeleton in various
Tim Hohmann +4 more
doaj +1 more source
BioTechniques, 2019 We systematically evaluated the performance and reliability of several widely used, commercially available actin-filament probes in a highly motile breast adenocarcinoma cell line to optimize the visualization of F-actin-rich dynamic lamellipodia.
Vera DesMarais +4 more
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Cells, 2020 Movement of cells and tissues is essential at various stages during the lifetime of an organism, including morphogenesis in early development, in the immune response to pathogens, and during wound-healing and tissue regeneration.
Yougan Cheng +2 more
doaj +1 more source