Results 101 to 110 of about 347,216 (308)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Modelling the movement of transformed cell populations. [PDF]

, 2011
The aim of this work was to analyze migrating cell populations, in search of motion models able to accurately describe the features of normal and transformed fibroblast movement, under different experimental conditions.
Fioretti, Francesca
core  

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion [PDF]

, 2014
This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Pathak, R.B., Bryan A. Ballif (238963), Nicholas J Westwood, Westwood, N.J., Gary E Ward, Leung, J.M., Jacqueline M Leung, Poupart, S., Ward, G.E., Nicholas J. Westwood (254891), Séverine Poupart (571871), Gary E. Ward (208054), Ballif, B.A., Séverine Poupart, Tran, F., Aoife T. Heaslip (207534), Bryan A Ballif, Fanny Tran, Aoife T Heaslip, Fanny Tran (571869), Jacqueline M. Leung (120235), Heaslip, A.T., Ravindra B Pathak, Ravindra B. Pathak (571870)   +23 more
core   +1 more source

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4

Cancer Medicine, 2018
WAVE2 is a member of the WASP/WAVE family of actin cytoskeletal regulatory proteins; unfortunately, little is known about its function in pancreatic cancers. In this study, we report the role of WAVE2 in the motility and invasiveness of pancreatic cancer
Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Toshiji Saibara   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstream [PDF]

, 2012
Blood is a remarkable habitat: it is highly viscous, contains a dense packaging of cells and perpetually flows at velocities varying over three orders of magnitude. Only few pathogens endure the harsh physical conditions within the vertebrate bloodstream
Timothy Krüger, Stark Holger, Engstler Markus, Engstler, M., Heddergott, Niko, Wei, Ai, Sravanti Uppaluri (120013), Erik Stellamanns, Pfohl, T., Stellamanns, E., Heddergott, Nico, Holger Stark, Uppaluri, Sravanti, Wei, A., Markus Engstler, Krüger, T., Engstler, Markus, Heddergott, N., Pfohl Thomas, Babu Sujin B., Krüger Timothy, Babu, Sujin B., Holger Stark (4694), Markus Engstler (120018), Sujin B Babu, Niko Heddergott (120004), Ai Wei, Sujin B. Babu (120007), Stellamanns, Erik, Sravanti Uppaluri, Erik Stellamanns (120012), Stark, H., Stark, Holger, Babu, S., Pfohl, Thomas, Uppaluri, S., Thomas Pfohl (120015), Beverley, Stephen M., Stellamanns Erik, Krüger, Timothy, Wei Ai, Niko Heddergott, Uppaluri Sravanti, Ai Wei (120010), Heddergott Niko, Thomas Pfohl, Timothy Krüger (120005)   +46 more
core   +1 more source

Key Metabolites and Mechanistic Changes for Salt Tolerance in an Experimentally Evolved Sulfate-Reducing Bacterium, Desulfovibrio vulgaris

mBio, 2017
Rapid genetic and phenotypic adaptation of the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough to salt stress was observed during experimental evolution.
Aifen Zhou, Rebecca Lau, Richard Baran, Jincai Ma, Frederick von Netzer, Weiling Shi, Drew Gorman-Lewis, Megan L. Kempher, Zhili He, Yujia Qin, Zhou Shi, Grant M. Zane, Liyou Wu, Benjamin P. Bowen, Trent R. Northen, Kristina L. Hillesland, David A. Stahl, Judy D. Wall, Adam P. Arkin, Jizhong Zhou   +19 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion [PDF]

, 2011
MRCK alpha and MRCK beta (myotonic dystrophy kinase-related Cdc42-binding kinases) belong to a subfamily of Rho GTPase activated serine/threonine kinases within the AGC-family that regulate the actomyosin cytoskeleton.
Ewald Schroder, Pang Leon, Diane Crighton, Schroder Ewald, Kaye Sarah J., Turnbull Andrew, Olson, M.F., Michael F Olson, Heikkila, T., Olson Michael F., Sarah J. Kaye, Mezna Mokdad, Timo Heikkila, Rushbrooke Mathew, Wheatley, E., Alexandra Boakes, Turnbull, A., Mokdad Mezna, Rushbrooke, M., Crighton, D., Kaye, S.J., Schroder, E., Leon Pang, Boakes, A., Mezna, M., Pang, L., Heikkila Timo, Crighton Diane, Edward Wheatley, Wheatley Edward, Mathew Rushbrooke, Andrew Turnbull, Sarah J Kaye, Boakes Alexandra, Michael F. Olson   +34 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source