Results 81 to 90 of about 551,941 (324)
Low-Cost Motility Tracking System (LOCOMOTIS) for time-lapse microscopy applications and cell visualisation [PDF]
, 2014 This article has been made available through the Brunel Open Access Publishing Fund.Direct visualisation of cells for the purpose of studying their motility has typically required expensive microscopy equipment.
Lynch, AE, Routledge, E, Triajianto, J
core +4 more sources
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Stability and roughness of interfaces in mechanically-regulated tissues
, 2018 Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface, by analysing a model of mechanically-regulated tissue growth in the regime of small ...
Salbreux, Guillaume, Williamson, John J.
core +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Cooperative cell motility during tandem locomotion of amoeboid cells. [PDF]
, 2016 Streams of migratory cells are initiated by the formation of tandem pairs of cells connected head to tail to which other cells subsequently adhere. The mechanisms regulating the transition from single to streaming cell migration remain elusive, although ...
Bastounis, Effie +4 more
core +2 more sources
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells
Life Science AllianceTBXA2R signaling activates ERMs through Gαq/11-Gα12/13, Rho GTPases, and SLK/LOK, boosting TNBC cell migration, invasion, and metastatic colonization. Cell migration and invasion are critical for cancer cell metastasis, relying on the ability of cells to
Kévin Leguay +12 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An optimal control approach to cell tracking [PDF]
, 2014 Cell tracking is of vital importance in many biological studies, hence robust cell tracking algorithms are needed for inference of dynamic features from (static) in vivo and in vitro experimental imaging data of cells migrating. In recent years much
Blazakis, K +4 more
core +1 more source
The preprophase band-associated kinesin-14 OsKCH2 is a processive minus-end-directed microtubule motor. [PDF]
, 2018 In animals and fungi, cytoplasmic dynein is a processive minus-end-directed motor that plays dominant roles in various intracellular processes. In contrast, land plants lack cytoplasmic dynein but contain many minus-end-directed kinesin-14s.
Bowen, Joel +7 more
core +3 more sources