Results 61 to 70 of about 347,216 (308)

Determination of Dissociation Constants for the Interaction of Myosin-5a with its Cargo Protein Using Microscale Thermophoresis (MST)

Bio-Protocol
Myosin-5a (Myo5a) is an actin-dependent molecular motor that recognizes a diverse range of cargo proteins through its tail domain, playing a crucial role in the transport and localization of various organelles within the cell.
Rui Zhou, Jiabin Pan, Xiang-Dong Li
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori [PDF]

, 2010
Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa.
Caly, Delphine L., O\u27Toole, Paul W., Penn Charles W, Stanley A Moore, Douillard, FP, Douillard, François P., Ryan, KA, Caly Delphine L, Hinds, Jason, Francois P Douillard, Charles W Penn, Moore, SA, Paul W O'Toole, Moore Stanley A, Lane, Michael C., Hinds Jason, O'Toole, Paul W., Kieran A Ryan, Ryan Kieran A, Lane Michael C, Michael C Lane, Delphine C Caly, O'Toole Paul W, O'Toole, PW, Ryan, Kieran A., Penn, Charles, Caly, DL, Hinds, J, Penn, CW, Penn, Charles W., Jason Hinds, Lane, MC, Moore, Stanley A., Douillard François P   +33 more
core   +1 more source

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells

BMC Research Notes, 2020
Objective The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on T-cells.
Alison Taylor, Christopher E. Rudd
doaj   +1 more source

Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

Biomedicines, 2021
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Ming-Shyan Huang, Michael Hsiao, Chih-Jen Yang   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

MODELLING THE INFLUENCE OF NUCLEUS ELASTICITY ON CELL INVASION IN FIBER NETWORKS AND MICROCHANNELS [PDF]

, 2013
Cell migration in highly constrained extracellular matrices is exploited in scaffold-based tissue engineering and is fundamental in a wide variety of physiological and pathological phenomena, among others in cancer invasion and development. Research into
Scianna, Marco, Preziosi, Luigi
core   +1 more source

Myosin VI in the nucleolus of neurosecretory PC12 cells: its involvement in the maintenance of nucleolar structure and ribosome organization

Frontiers in Physiology
We have previously shown that unconventional myosin VI (MVI), a unique actin-based motor protein, shuttles between the cytoplasm and nucleus in neurosecretory PC12 cells in a stimulation-dependent manner and interacts with numerous proteins involved in ...
Jolanta Nowak, Robert Lenartowski, Robert Lenartowski, Katarzyna Kalita, Lilya Lehka, Olena Karatsai, Marta Lenartowska, Marta Lenartowska, Maria Jolanta Rędowicz   +8 more
doaj   +1 more source

Matrix Stiffness Modulates Mechanical Interactions and Promotes Contact between Motile Cells

Biomedicines, 2021
The mechanical micro-environment of cells and tissues influences key aspects of cell structure and function, including cell motility. For proper tissue development, cells need to migrate, interact, and form contacts.
Subhaya Bose, Kinjal Dasbiswas, Arvind Gopinath   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source