Results 21 to 30 of about 309,525 (309)

Virus-Induced Cell Motility [PDF]

open access: yesJournal of Virology, 1998
ABSTRACT Many viruses induce profound changes in cell metabolism and function. Here we show that vaccinia virus induces two distinct forms of cell movement. Virus-induced cell migration was demonstrated by an in vitro wound healing assay in which infected cells migrated independently into the wound area while uninfected cells remained ...
C M, Sanderson, M, Way, G L, Smith
openaire   +2 more sources

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening

open access: yesNature Communications, 2016
Establishment and maintenance of apico-basal polarity in epithelial organs needs to be tightly coupled with cell division. Here the authors show that the Rab35 GTPase tethers intracellular vesicles containing key apical determinants at the cleavage site,
Kerstin Klinkert   +3 more
doaj   +1 more source

Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. [PDF]

open access: yesPLoS ONE, 2008
Actin-based cell motility and force generation are central to immune response, tissue development, and cancer metastasis, and understanding actin cytoskeleton regulation is a major goal of cell biologists.
Benjamin J Dubin-Thaler   +9 more
doaj   +1 more source

Exopolysaccharide-independent social motility of Myxococcus xanthus. [PDF]

open access: yesPLoS ONE, 2011
Social motility (S motility), the coordinated movement of large cell groups on agar surfaces, of Myxococcus xanthus requires type IV pili (TFP) and exopolysaccharides (EPS).
Wei Hu   +6 more
doaj   +1 more source

The Shape of Motile Cells [PDF]

open access: yesCurrent Biology, 2009
Motile cells - fan-like keratocytes, hand-shaped nerve growth cones, polygonal fibroblasts, to name but a few - come in different shapes and sizes. We discuss the origins of this diversity as well as what shape tells us about the physics and biochemistry underlying cell movement.
Mogilner, Alex, Keren, Kinneret
openaire   +2 more sources

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

open access: yesNature Communications, 2017
Actin and microtubules play important roles in Golgi structure and function but how they are connected is poorly understood. Here the authors show that KIF20A is involved in the fission process and, in association with Myosin II, serves to anchor RAB6 on
Stéphanie Miserey-Lenkei   +12 more
doaj   +1 more source

A cell behavior screen: identification, sorting, and enrichment of cells based on motility

open access: yesBMC Cell Biology, 2005
Background Identifying and isolating cells with specific behavioral characteristics will facilitate the understanding of the molecular basis regulating these behaviors.
Chen Kwan Y   +2 more
doaj   +1 more source

Identification of a third myosin-5a-melanophilin interaction that mediates the association of myosin-5a with melanosomes

open access: yeseLife
Transport and localization of melanosome at the periphery region of melanocyte are depended on myosin-5a (Myo5a), which associates with melanosome by interacting with its adaptor protein melanophilin (Mlph).
Jiabin Pan   +7 more
doaj   +1 more source

Inhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies

open access: yesNeoplasia: An International Journal for Oncology Research, 2012
Taxanes are potent inhibitors of cell motility, a property implicated in their antiangiogenic and antimetastatic activity and unrelated to their antiproliferative effect. The molecular mechanism of this anti-motility activity is poorly understood.
Katiuscia Bonezzi   +10 more
doaj   +1 more source

SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK

open access: yesMolecular Oncology, 2022
Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression.
Xiu Shi   +12 more
doaj   +1 more source

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