Results 1 to 10 of about 827,170 (307)

Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression

Cells, 2021
The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová, Lenka Šebestová, Karel Fišer, Tomáš Sieger, Jindřiška Fišerová, Pavel Hozák   +5 more
doaj   +1 more source

The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus

Cells, 2021
Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein (MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to Phosphatidylinositol 4,5-bisphosphate (PIP2) and localizes to the nuclear ...
Can Balaban, Martin Sztacho, Michaela Blažíková, Pavel Hozák   +3 more
doaj   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

Cells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho, Barbora Šalovská, Jakub Červenka, Can Balaban, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts

Frontiers in Cell and Developmental Biology, 2023
Introduction: Imaging of human clinical formalin-fixed paraffin-embedded (FFPE) tissue sections provides insights into healthy and diseased states and therefore represents a valuable resource for basic research, as well as for diagnostic and clinical ...
Peter Hoboth, Martin Sztacho, Alexander Quaas, Baki Akgül, Pavel Hozák, Pavel Hozák   +5 more
doaj   +1 more source

Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulose membrane [PDF]

PeerJ, 2018
Background Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues.
Marcello de Alencar Silva, Yulla Klinger de Carvalho Leite, Camila Ernanda Sousa de Carvalho, Matheus Levi Tajra Feitosa, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Bartolomeu Cruz Viana Neto, Maria Angélica Miglino, Angela Faustino Jozala, Maria Acelina Martins de Carvalho   +9 more
doaj   +2 more sources

Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction

Frontiers in Bioengineering and Biotechnology, 2021
Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state.
Fabrizio A. Pennacchio, Paulina Nastały, Paulina Nastały, Alessandro Poli, Paolo Maiuri   +4 more
doaj   +1 more source

Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome

Cells, 2020
Phosphoinositides are glycerol-based phospholipids, and they play essential roles in cellular signalling, membrane and cytoskeletal dynamics, cell movement, and the modulation of ion channels and transporters.
Veronika Fáberová, Ilona Kalasová, Alžběta Krausová, Pavel Hozák   +3 more
doaj   +1 more source

Analysis of the extranucleolar ribonucleoprotein particles of Cycas revoluta Thunb. (Cycadaceae) and Ceratozamia mexicana Brongn. (Zamiaceae)

Botan‪ical Sciences, 2022
Background: Nuclear ribonucleoprotein particles play a key role in RNA processing and in the gene expression pathway. Interchromatin granules (GICs) involved in the metabolism of pre-messenger RNA (pre-mRNA) were described in Allium cepa and ...
Lourdes-Teresa Agredano-Moreno, María de Lourdes Segura-Valdez, Jaime Jiménez-Ramírez, Luis-Felipe Jiménez-García   +3 more
doaj   +1 more source

Nuclear Phosphoinositides—Versatile Regulators of Genome Functions

Cells, 2019
The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear.
Enrique Castano, Sukriye Yildirim, Veronika Fáberová, Alžběta Krausová, Lívia Uličná, Darina Paprčková, Martin Sztacho, Pavel Hozák   +7 more
doaj   +1 more source

Indeterminate thyroid cytology: detecting malignancy using analysis of nuclear images

Endocrine Connections, 2021
Background: Thyroid nodules diagnosed as 'atypia of undetermined significan ce/ follicular lesion of undetermined significance' (AUS/FLUS) or 'f ollicular neoplasm/ suspected follicular neoplasm' (FN/SFN), according to Bethesda’s classification ...
Caroline Y Hayashi, Danilo T A Jaune, Cristiano C Oliveira, Bárbara P Coelho, Hélio A Miot, Mariângela E A Marques, José Vicente Tagliarini, Emanuel C Castilho, Carlos S P Soares, Flávia R K Oliveira, Paula Soares, Gláucia M F S Mazeto   +11 more
doaj   +1 more source