Cells, 2022 The focal adhesion protein Vinculin (VCL) is ascribed to various cytoplasmic functions; however, its nuclear role has so far been ambiguous. We observed that VCL localizes to the nuclei of mouse primary spermatocytes undergoing first meiotic division ...
Jana Petrusová +7 more
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Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases [PDF]
Diabetes & Metabolism Journal, 2021 Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases.
Jin-Ho Koh +3 more
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PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription
Biomolecules, 2023 The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription.
Can Balaban +5 more
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Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression
Cells, 2021 The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová +5 more
doaj +1 more source
Cells, 2021 Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein (MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to Phosphatidylinositol 4,5-bisphosphate (PIP2) and localizes to the nuclear ...
Can Balaban +3 more
doaj +1 more source
Indeterminate thyroid cytology: detecting malignancy using analysis of nuclear images
Endocrine Connections, 2021 Background: Thyroid nodules diagnosed as 'atypia of undetermined significan ce/ follicular lesion of undetermined significance' (AUS/FLUS) or 'f ollicular neoplasm/ suspected follicular neoplasm' (FN/SFN), according to Bethesda’s classification ...
Caroline Y Hayashi +11 more
doaj +1 more source
Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulose membrane [PDF]
PeerJ, 2018 Background Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues.
Marcello de Alencar Silva +9 more
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Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome
Cells, 2020 Phosphoinositides are glycerol-based phospholipids, and they play essential roles in cellular signalling, membrane and cytoskeletal dynamics, cell movement, and the modulation of ion channels and transporters.
Veronika Fáberová +3 more
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Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin
Frontiers in Genetics, 2022 Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of DNA packing to be visible by light microscopy ...
Anastasia Roemer +4 more
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Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction
Frontiers in Bioengineering and Biotechnology, 2021 Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state.
Fabrizio A. Pennacchio +4 more
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