The role of vimentin–nuclear interactions in persistent cell motility through confined spaces [PDF]
New Journal of Physics, 2021 The ability of cells to move through small spaces depends on the mechanical properties of the cellular cytoskeleton and on nuclear deformability. In mammalian cells, the cytoskeleton is composed of three interacting, semi-flexible polymer networks: actin,
Sarthak Gupta +2 more
doaj +2 more sources
In Vivo Localization of Fas-Associated Death Domain Protein in the Nucleus and Cytoplasm of Normal Thyroid and Liver Cells [PDF]
open autoimmunty journal 1 (2009) 27-32, 2009 FADD (Fas-associated death domain) is the main death receptor adaptor molecule that transmits apoptotic signal. Recently, FADD protein was shown to be expressed both in the cytoplasm and nucleus of in vitro cell lines. In contrast to the cytoplasmic FADD,
Chiocchia, Gilles +2 more
core +6 more sources
Numerical simulations of elastic capsules with nucleus in shear flow [PDF]
, 2017 The shear-induced deformation of a capsule with a stiff nucleus, a model of eukaryotic cells, is studied numerically. The membrane of the cell and of its nucleus are modelled as a thin and impermeable elastic material obeying a Neo-Hookean constitutive ...
Banaei, Arash Alizad +3 more
core +2 more sources
Cell nucleus as a microrheological probe to study the rheology of the cytoskeleton. [PDF]
Biophys J, 2021 Mechanical properties of the cell are important biomarkers for probing its architectural changes caused by cellular processes and/or pathologies. The development of microfluidic technologies have enabled measuring cell mechanics at high-throughput, so that mechanical phenotyping can be applied to large samples in reasonable time-scales.
Moradi M, Nazockdast E.
europepmc +2 more sources
The Material Properties of the Cell Nucleus: A Matter of Scale. [PDF]
Cells, 2023 Chromatin regulatory processes physically take place in the environment of the cell nucleus, which is filled with the chromosomes and a plethora of smaller biomolecules.
Hertzog M, Erdel F.
europepmc +2 more sources
Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus. [PDF]
CellsLamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations.
Escudeiro-Lopes S +3 more
europepmc +2 more sources
Genome-Directed Cell Nucleus Assembly. [PDF]
Biology (Basel), 2022 The cell nucleus is frequently considered a cage in which the genome is placed to protect it from various external factors. Inside the nucleus, many functional compartments have been identified that are directly or indirectly involved in implementing ...
Razin SV, Ulianov SV.
europepmc +2 more sources
Cells, 2022 The focal adhesion protein Vinculin (VCL) is ascribed to various cytoplasmic functions; however, its nuclear role has so far been ambiguous. We observed that VCL localizes to the nuclei of mouse primary spermatocytes undergoing first meiotic division ...
Jana Petrusová +7 more
doaj +1 more source
Physical Training Chronically Stimulates the Motor Neuron Cell Nucleus in the Ts65Dn Mouse, a Model of Down Syndrome. [PDF]
Cells, 2023 Down syndrome (DS) is a genetically-based disease based on the trisomy of chromosome 21 (Hsa21). DS is characterized by intellectual disability in association with several pathological traits among which early aging and altered motor coordination are ...
Inguscio CR +4 more
europepmc +2 more sources
Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases [PDF]
Diabetes & Metabolism Journal, 2021 Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases.
Jin-Ho Koh +3 more
doaj +1 more source