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Assembly of the cell nucleus

Trends in Genetics, 1990
Purified DNA can be assembled into structures that closely resemble cell nuclei. The cell-free systems that allow this can be exploited to study assembly pathways for several components of the nucleus. They also offer great opportunities for the experimental analysis of nuclear function.
R A, Laskey, G H, Leno
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Mechanics of the Cell Nucleus

2018
Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be ...
Dong-Hwee, Kim   +2 more
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Origin of the cell nucleus

BioEssays, 1988
AbstractThe origin of mitosis and the nuclear envelope were the pivotal processes in the evolutionary origin of the nucleus; they probably occurred in a wall‐less mutant bacterium that evolved a cytoskeleton and phagocytosis about 1500 million years ago.
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Nucleus and nucleus-cytoskeleton connections in 3D cell migration

Experimental Cell Research, 2016
Cell migration plays an important role in many physiological and pathological settings, ranging from embryonic development to cancer metastasis. Currently, accumulating data suggest that cells migrating in three-dimensional (3D) environments show well-defined differences compared to their well-established two-dimensional (2D) counterparts.
Lingling, Liu   +3 more
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Protein Synthesis in the Cell Nucleus

Nature, 1955
THERE is considerable evidence that the cytoplasm of the cell contains structures capable of carrying out protein synthesis1, and it has been shown in one case2 that formation of protein may be little affected by removal of the nucleus. These findings seem to exclude the appealing hypothesis that the nucleus is the source of the cell's proteins.
D, MAZIA, D M, PRESCOTT
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On the Variability in Cell and Nucleus Shapes

Cells Tissues Organs, 2022
Cell morphology is an important regulator of cell function. Many abnormalities in cellular behavior can be discerned from changes in the shape of the cell and its organelles, typically the nucleus. Two major challenges for developing such phenotypic assays are reconstructing 3D surfaces of individual cells and nuclei from confocal images and developing
Anusha Devulapally   +3 more
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Editorial overview: Cell nucleus: The nucleus: a dynamic organelle

Current Opinion in Cell Biology, 2014
The nucleus is perhaps the defining feature of ‘eukaryotes’ (Greek ‘eu-’ (with) ‘-karyon’ (kernel, nucleus)), and the emperor of all eukaryotic organelles in terms of scale and complexity of organization. It is, of course, the repository for almost all genomic information, encoded in DNA sequences wrapped into chromatin as discrete polymer packages ...
Michael P, Rout, Gary H, Karpen
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The Cell Nucleus

JAMA: The Journal of the American Medical Association, 1975
ABSTRACT The ultimate book on the nucleus would require about a million pages just to present the complete base sequence of DNA in a single human nucleus, alphabetically. The three volumes of The Cell Nucleus, of course, make no pretense of offering that kind of information, but they provide a wide range of up-to-date information on the structure and ...
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Cell Biology of the Plant Nucleus

Annual Review of Plant Biology, 2017
The eukaryotic nucleus is enclosed by the nuclear envelope, which is perforated by the nuclear pores, the gateways of macromolecular exchange between the nucleoplasm and cytoplasm. The nucleoplasm is organized in a complex three-dimensional fashion that changes over time and in response to stimuli.
Iris, Meier   +2 more
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Functional architecture in the cell nucleus

Biochemical Journal, 2001
The major functions of the cell nucleus, including transcription, pre-mRNA splicing and ribosome assembly, have been studied extensively by biochemical, genetic and molecular methods. An overwhelming amount of information about their molecular mechanisms is available. In stark contrast, very little is known about how these processes are integrated into
M, Dundr, T, Misteli
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