Results 21 to 30 of about 1,369,656 (306)

PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription

open access: yesBiomolecules, 2023
The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription.
Can Balaban   +5 more
doaj   +1 more source

Nucleoporin TPR Affects C2C12 Myogenic Differentiation via Regulation of Myh4 Expression

open access: yesCells, 2021
The nuclear pore complex (NPC) has emerged as a hub for the transcriptional regulation of a subset of genes, and this type of regulation plays an important role during differentiation.
Jana Uhlířová   +5 more
doaj   +1 more source

The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus

open access: yesCells, 2021
Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein (MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to Phosphatidylinositol 4,5-bisphosphate (PIP2) and localizes to the nuclear ...
Can Balaban   +3 more
doaj   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

open access: yesCells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho   +5 more
doaj   +1 more source

Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin

open access: yesFrontiers in Genetics, 2022
Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of DNA packing to be visible by light microscopy ...
Anastasia Roemer   +4 more
doaj   +1 more source

Behavior and biocompatibility of rabbit bone marrow mesenchymal stem cells with bacterial cellulose membrane [PDF]

open access: yesPeerJ, 2018
Background Tissue engineering has been shown to exhibit great potential for the creation of biomaterials capable of developing into functional tissues.
Marcello de Alencar Silva   +9 more
doaj   +2 more sources

Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome

open access: yesCells, 2020
Phosphoinositides are glycerol-based phospholipids, and they play essential roles in cellular signalling, membrane and cytoskeletal dynamics, cell movement, and the modulation of ion channels and transporters.
Veronika Fáberová   +3 more
doaj   +1 more source

Indeterminate thyroid cytology: detecting malignancy using analysis of nuclear images

open access: yesEndocrine Connections, 2021
Background: Thyroid nodules diagnosed as 'atypia of undetermined significan ce/ follicular lesion of undetermined significance' (AUS/FLUS) or 'f ollicular neoplasm/ suspected follicular neoplasm' (FN/SFN), according to Bethesda’s classification ...
Caroline Y Hayashi   +11 more
doaj   +1 more source

Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state.
Fabrizio A. Pennacchio   +4 more
doaj   +1 more source

Nuclear Phosphoinositides—Versatile Regulators of Genome Functions

open access: yesCells, 2019
The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear.
Enrique Castano   +7 more
doaj   +1 more source

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