Results 51 to 60 of about 1,337,831 (333)

Alteration of actin cytoskeletal organisation in fetal akinesia deformation sequence

Scientific Reports
Fetal akinesia deformation sequence (FADS) represents the severest form of congenital myasthenic syndrome (CMS), a diverse group of inherited disorders characterised by impaired neuromuscular transmission.
Ramona Jühlen, Lukas Grauer, Valérie Martinelli, Chantal Rencurel, Birthe Fahrenkrog   +4 more
doaj   +1 more source

The Emerging Roles of Heterochromatin in Cell Migration

Frontiers in Cell and Developmental Biology, 2020
Cell migration is a key process in health and disease. In the last decade an increasing attention is given to chromatin organization in migrating cells. In various types of cells induction of migration leads to a global increase in heterochromatin levels.
Gabi Gerlitz
doaj   +1 more source

Systems biology in the cell nucleus [PDF]

Journal of Cell Science, 2005
The mammalian nucleus is arguably the most complex cellular organelle. It houses the vast majority of an organism's genetic material and is the site of all major genome regulatory processes. Reductionist approaches have been spectacularly successful at dissecting at the molecular level many of the key processes that occur within the nucleus ...
Tom Misteli, Stanislaw A. Gorski
openaire   +3 more sources

The connections of the inferior colliculus and the organization of the brainstem auditory system in the greater horseshoe bat (Rhinolophus ferrumequinum) [PDF]

, 1981
The connections of the inferior colliculus, the mammalian midbrain auditory center, were determined in the greater horseshoe bat (Rhinolophus ferrumequinum), using the horseradish peroxidase method.
Adams, Adams, Aitkin, Aitkin, Aitkin, Aitkin, Aitkin, Baron, Beyerl, Boyd, Brown, Browner, Bruns, Carey, Edwards, Elverland, Fernandez, FitzPatrick, Friend, Graham, Grinnell, Harnischfeger, Harrison, Harrison, Henkel, Henson, Henson, Illing, Irving, Jen, Kawamura, Masterton, Merzenich, Mesulam, Moore, Moore, Moushegian, Neuweiler, Neuweiler, Noda, Ollo, Osen, Ostwald, Poljak, Poljak, Pollak, Pollak, Powell, RoBarts, Rose, Roth, Schnitzler, Schober, Schroeder, Schuller, Schuller, Schweizer, Schweizer, Strominger, Suga, Suga, Suga, Tsuchitani, van Noort, Vater, Warr, Webster, Ziesmer, Zook, Zook, Zook   +70 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Histopathological Change of Oral Malignant Tumour and Epithelial Dysplasia Subjected to Photodynamic Therapy [PDF]

eJournal of Oral Maxillofacial Research, 2010
Objectives: The purpose of this study is to analyze the morphological change of cell nuclei and the change of proliferating activity of oral malignancy and epithelial dysplasia between before and after photodynamic therapy in order to predict recurrence ...
Masataka Uehara, Hisazumi Ikeda, Mihoko Nonaka, Izumi Asahina, Izumi Asahina   +3 more
doaj  

The role of vimentin–nuclear interactions in persistent cell motility through confined spaces

New Journal of Physics, 2021
The ability of cells to move through small spaces depends on the mechanical properties of the cellular cytoskeleton and on nuclear deformability. In mammalian cells, the cytoskeleton is composed of three interacting, semi-flexible polymer networks: actin,
Sarthak Gupta, Alison E Patteson, J M Schwarz   +2 more
doaj   +1 more source

The Core Histone-binding Region of the Murine Cytomegalovirus 89K Immediate Early Protein [PDF]

, 1991
The gene regulatory immediate early protein, pp89, of murine cytomegalovirus interacts with both DNA-associated and isolated histones in vitro. We characterized the histone-binding region of pp89 and its cellular localization during cell division to ...
Bühler, Bernhard, Koszinowski, Ulrich H., Messerle, Martin, Münch, Konrad   +3 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Modelling diffusional transport in the interphase cell nucleus

, 2007
In this paper a lattice model for diffusional transport of particles in the interphase cell nucleus is proposed. Dense networks of chromatin fibers are created by three different methods: randomly distributed, non-interconnected obstacles, a random walk ...
Annika Wedemeier, Chen-Xu Wu, Holger Merlitz, Jörg Langowski, Lukacs G., Ptashne M., von Hippel P. H.   +6 more
core   +1 more source