Results 191 to 200 of about 12,836,766 (354)

Advances in vascular endothelial cell-mediated regulation of satellite cell repair and regeneration. [PDF]

Inflamm Regen
Yang C, Zhang L, Liu L, Bai L, Liu Y, Wang R, Qi B.   +6 more
europepmc   +1 more source

DNA double-strand break repair-pathway choice in somatic mammalian cells

Nature reviews. Molecular cell biology, 2019
R. Scully, Arvind Panday, Rajula Elango, Nicholas A. Willis   +3 more
semanticscholar   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Fibroblast-derived osteoglycin promotes epithelial cell repair. [PDF]

NPJ Regen Med
van der Koog L, Woest ME, Gorter IC, Verschut V, Elferink RAB, Zuidhof AB, Nugraha DF, Koloko Ngassie ML, Bos SIT, Dhakad D, Wolters JC, Horvatovich PL, Prakash YS, Timens W, Yildirim ÖA, Brandsma CA, Frijlink HW, Nagelkerke A, Gosens R.   +18 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice. [PDF]

Cell Death Dis
Govindappa PK, Ellur G, Hegarty JP, Gupta A, V G R, Elfar JC.   +5 more
europepmc   +1 more source

Oral delivery of exenatide-loaded hybrid zein nanoparticles for stable blood glucose control and β-cell repair of type 2 diabetes mice. [PDF]

J Nanobiotechnology, 2020
Bao X, Qian K, Yao P.
europepmc   +1 more source

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Cell Stem Cell, 2013
Gerald Schwank, B. Koo, Valentina Sasselli, J. Dekkers, Inha Heo, T. Demircan, Nobuo Sasaki, S. Boymans, E. Cuppen, C. K. van der Ent, E. Nieuwenhuis, J. Beekman, H. Clevers   +12 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Exosomal BMPR2 Macromolecule Facilitates Alveolar Epithelial Cell Repair Through Functional Complex Formation with BMPR1B in Acute Lung Injury. [PDF]

Int J Nanomedicine
Yun X, Chen Z, Li F, Shen F, Zhang L, Yuan J.   +5 more
europepmc   +1 more source