Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study [PDF]
BiosensorsParticle separation and sorting techniques based on microfluidics have found extensive applications and are increasingly gaining prominence. This research presents the design and fabrication of a microfluidic device for separating cells using ...
Shaghayegh Mirhosseini +7 more
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Fabrication of Spiral Low-Cost Microchannel with Trapezoidal Cross Section for Cell Separation Using a Grayscale Approach [PDF]
Micromachines, 2023 Trapezoidal cross-sectional spiral microfluidic channels showed high resolution and throughput in cell separation in bio-applications. The main challenges are the complexity and high cost of the fabrication process of trapezoidal cross-sectional channels
Mohamed Adel +5 more
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Modeling of Electric Field and Dielectrophoretic Force in a Parallel-Plate Cell Separation Device with an Electrode Lid and Analytical Formulation Using Fourier Series [PDF]
SensorsDielectrophoresis (DEP) cell separation technology is an effective means of separating target cells which are only marginally present in a wide variety of cells.
Daiki Nishikawa +2 more
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Controlled Scaffold Platform Designs on Nasopharyngeal Carcinoma Cell Separation
IEEE Access, 2021 Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic disease occurring in the nasopharynx. For early diagnosis or treatment, it is helpful to separate invasive nasopharyngeal carcinoma (NPC43) cells from epithelial (NP460) cells.
Muting Wang, Stella W. Pang
doaj +1 more source
Numerical simulation of inertial microfluidics: a review
Engineering Applications of Computational Fluid Mechanics, 2023 Since the proposal of inertial microfluidics in 2007, it has been widely used for particle focusing and separation with superior performances. The particle migration behaviour in microchannel is extremely complicated involving various parameters ...
Ruiju Shi
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Isolation of Hepatocytes from Liver Tissue by a Novel, Semi-Automated Perfusion Technology
Biomedicines, 2022 Primary hepatocytes are a major tool in biomedical research. However, obtaining high yields of variable hepatocytes is technically challenging. Most protocols rely on the two-step collagenase perfusion protocol introduced by Per Ottar Seglen in 1976.
Carsten Poggel +9 more
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Biosensors, 2022 The separation of circulating tumor cells (CTCs) from blood samples is crucial for the early diagnosis of cancer. During recent years, hybrid microfluidics platforms, consisting of both passive and active components, have been an emerging means for the ...
Rana Altay +2 more
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Deformability-Based Isolation of Circulating Tumor Cells in Spiral Microchannels
Micromachines, 2023 The isolation of circulating tumor cells (CTCs) and their analysis are crucial for the preliminary identification of invasive cancer. One of the effective properties that can be utilized to isolate CTCs is their deformability.
Roya Mohammadali, Morteza Bayareh
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Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells [PDF]
SciPost Phys. 16, 097 (2024), 2023 The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth, the regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue steady-state are still poorly ...
arxiv +1 more source
Magnetic Polymers for Magnetophoretic Separation in Microfluidic Devices
Magnetochemistry, 2021 Magnetophoresis offers many advantages for manipulating magnetic targets in microsystems. The integration of micro-flux concentrators and micro-magnets allows achieving large field gradients and therefore large reachable magnetic forces.
Lucie Descamps +3 more
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