Results 101 to 110 of about 7,293,453 (311)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Depletion of Aneuploid Cells is Shaped by Cell-to-Cell Interactions
Cell GenomicsSummary Aneuploidy, the major cause of miscarriages in humans, is pervasive in early embryos but robustly dampened during development, allowing for healthy births. Later in life, aneuploidy correlates with pathological conditions including cancer.
Elena Fusari +3 more
openaire +2 more sources
Computational Methods for Shape Manipulation in generation : a literature review [PDF]
, 2010 In this paper we will present a state of the art of the descriptive and generative models for shape. We will present several different approaches for the manipulation of shape in computational systems: numerical models, graph models, descriptive models ...
AOUSSAT, Améziane +3 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2019 Presented as part of the Shape Machine Symposium on April 11, 2019 at 11:15 a.m. in the John & Joyce Caddell Building, Flex Space.James Park is a PhD Student in the School of Architecture at the Georgia Institute of Technology. His research investigates
Park, James
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Cell surface plasticity in response to shape change in the whole organism
, 2023 Plasma membrane rupture can result in catastrophic cell death. The skeletal muscle fiber plasma membrane, the sarcolemma, provides an extreme example of a membrane subject to mechanical stress since these cells specifically evolved to generate ...
Rae, James +8 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Bacterial Evolution in High-Osmolarity Environments
mBio, 2020 Bacteria must maintain a cytosolic osmolarity higher than that of their environment in order to take up water. High-osmolarity environments therefore present formidable stress to bacteria. To explore the evolutionary mechanisms by which bacteria adapt to
Spencer Cesar +7 more
doaj +1 more source