Results 121 to 130 of about 890,746 (314)

Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]

open access: yes, 2004
Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Morph or move? How distinct endothelial cell responses to blood flow shape vascular networks

open access: yes, 2017
Blood vessel shape is malleable and dynamically regulated. In two recent papers in Nature Cell Biology, Jin et al. (2017) and Sugden et al. (2017) show that endoglin alters endothelial cell shape or behavior in response to blood flow, thus regulating ...
Holger Gerhardt   +3 more
core   +1 more source

Cells in Tight Spaces: The Role of Cell Shape in Cell Function [PDF]

open access: yes, 2010
In this issue, Pitaval et al. (2010. J. Cell Biol. doi:10.1083/jcb.201004003) demonstrate that cell geometry can regulate the elaboration of a primary cilium.
Shah, Jagesh, Jagesh V. Shah
core   +1 more source

Cells: shaping tissues and organs

open access: yesMolecular Biology of the Cell, 2014
mbc.E13-11-0670 Molecular Biology of the Cell Volume 25 Page 730 MBoC is pleased to publish this summary of the Minisymposium “Cells Shaping Tissues: Mechanisms Underlying Cell Polarity, Fate Specification, and Morphogenesis” held at the American Society for Cell Biology 2013 Annual Meeting, New Orleans, LA, December 15, 2013.
Gartner, Zev, Rosenblatt, J
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Influence of Cell Shape, Inhomogeneities and Diffusion Barriers in Cell Polarization Models [PDF]

open access: yes, 2014
In silico experiments bear the potential for further understanding of biological transport processes by allowing a systematic modification of any spatial property and providing immediate simulation results. Cell polarization and spatial reorganization of
Westerheide, Sebastian   +4 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The Actin Cortex: A Bridge between Cell Shape and Function [PDF]

open access: yes, 2016
The cortical actin network controls many animal cell shape changes by locally modulating cortical tension. Recent work has provided insight into cortex components and regulators.
Chalut, KJ, Paluch, EK
core  

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