Results 111 to 120 of about 890,746 (314)

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]

, 2014
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B., Adams, Richard J., Röper, Katja, Booth, Alexander J. R., Booth, Alexander J.R.   +4 more
core   +1 more source

Quorum sensing mediates morphology and motility transitions in the model archaeon Haloferax volcanii

mBio
Quorum sensing (QS) is a population density-dependent mechanism of intercellular communication, whereby microbes secrete and detect signals to regulate behaviors such as virulence and biofilm formation.
Priyanka Chatterjee, Caroline E. Consoli, Heather Schiller, Kiersten K. Winter, Monica E. McCallum, Stefan Schulze, Mechthild Pohlschroder   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dielectrophoresis: A Review of Applications for Stem Cell Research [PDF]

, 2010
Dielectrophoresis can discriminate distinct cellular identities in heterogeneous populations, and monitor cell state changes associated with activation and clonal expansion, apoptosis, and necrosis, without the need for biochemical labels.
De Sousa, Paul, Ronald Pethig, Pells, Steve, Anoop Menachery, Menachery, Anoop, Paul De Sousa, Pethig, Ronald, Steve Pells   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Geometric deep learning and multiple-instance learning for 3D cell-shape profiling.

The three-dimensional (3D) morphology of cells emerges from complex cellular and environmental interactions, serving as an indicator of cell state and function.
Tyson, A, Bakal, C, Bousgouni, V, Fourkioti, O, Dent, LG, Rowe-Brown, L, Dunsby, C, Curry, N, De Vries, M, Naidoo, R, Sparks, H   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Determination of cellular strains by combined atomic force microscopy and finite element modeling

, 2002
Many organs adapt to their mechanical environment as a result of physiological change or disease. Cells are both the detectors and effectors of this process.
Charras, GT, Charras, Guillaume T., Horton, MA, Horton, Mike A.   +3 more
core   +1 more source

Class-A penicillin binding proteins do not contribute to cell shape but repair cell- wall defects

, 2020
International audienceCell shape and cell-envelope integrity of bacteria are determined by the peptidoglycan cell wall. In rod-shaped Escherichia coli, two conserved sets of machinery are essential for cell-wall insertion in the cylindrical part of the ...
Alvarez, Laura, Bikard, David, Cava, Felipe,, Mariette Matondo, Gizem Özbaykal, Özbaykal, Gizem, Antoine Vigouroux, van Teeffelen, Sven, Sven van Teeffelen, Matondo, Mariette, Oldewurtel, Enno Rainer, Enno Rainer Oldewurtel, Alvarez, Laura,, Thibault Chaze, David Bikard, Chaze, Thibault, Andrey Aristov, Cordier, Baptiste, Oldewurtel, Enno, Felipe Cava, Aristov, Andrey, Vigouroux, Antoine, Cava, Felipe, Laura Alvarez, Baptiste Cordier   +24 more
core   +1 more source