Results 91 to 100 of about 11,719,375 (302)
Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1 [PDF]
, 1999 Families of clonally expressed major histocompatibility complex (MHC) class I–specific receptors provide specificity to and regulate the function of natural killer (NK) cells.
van de Wetering, Marc +16 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Genome and cell size responses to temperature in ectotherms [PDF]
, 2013 The relationship between temperature and body size has attracted wide interest since the “Bergmann's rule” was introduced. While this rule originally dealt with endotherms, later studies have focussed ectotherms, including cell- and genome sizes. Because
Jalal, Marwa
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Cell Size: Fat Makes Cells Fat [PDF]
Current Biology, 2017 Nutrients are required for the multiple biosynthetic pathways that result in cell growth, and faster growth due to increased nutrient supply results in larger cell volume. A new study demonstrates that fatty-acid availability limits growth rate and cell envelope capacity, revealing that fatty-acid synthesis is the primary determinant of cell size in ...
Lisa, Willis, Kerwyn Casey, Huang
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cell size regulation in bacteria [PDF]
Physical Review Letters, 2014 Various bacteria such as the canonical gram negative Escherichia coli or the well-studied gram positive Bacillus subtilis divide symmetrically after they approximately double their volume. Their size at division is not constant, but is typically distributed over a narrow range. Here, we propose an analytically tractable model for cell size control, and
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Size Distribution of Bacterial Cells [PDF]
Journal of Bacteriology, 1972 By using differential light-scattering measurements of single cells suspended in a laser beam, an effective cell radius has been determined for 141 individual bacteria from suspensions of Staphylococcus epidermidis . The accumulation of these measurements has provided the size distribution for the sampling.
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cell Competition and its role in the regulation of cell fitness from development to cancer [PDF]
, 2016 Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals that eliminates those cells that, although viable, are less fit than their neighbors. An important implication of cell competition is that cellular fitness is not only
di gregorio, A, Rodriguez, T, Bowling, S
core +1 more source