Results 121 to 130 of about 11,719,375 (302)

Small adipose-derived mesenchymal stromal cells exhibit longer telomeres and enhanced regenerative potential

Frontiers in Bioengineering and Biotechnology
Younger, replicative cells with longer telomeres can enhance regenerative therapies, however, there is a lack of a standard method to assess telomere length in live cells.
Uldis Berzins, Uldis Berzins, Uldis Berzins, Uldis Berzins, Janis Baronins, Janis Baronins, Hermanis Sorokins, Saurav Goel, Saurav Goel, Andrei Shishkin, Rosita Zvirgzdina, Aija Rautmane, Danail Minchev   +12 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Transcriptomic balance and optimal growth are determined by cell size

Cell size and growth are intimately related across the evolutionary scale, but whether cell size is important to attain maximal growth or fitness is still an open question. We show that growth rate is a non-monotonic function of cell volume, with maximal
Vidal, Pedro J., Pérez, Alexis P., Aldea, Martí, Yahya, Galal   +3 more
core   +1 more source

High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images

Adipocyte
The aim of this study was to create and validate a high-throughput method based on open-source software for the measurement of adipocyte diameters in white adipose tissue histological sections.
Alan Ramalho, Marie-Frédérique Gauthier, Ina Maltais-Payette, Giada Ostinelli, Frédéric Hould, Laurent Biertho, André Tchernof   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

, 2018
Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the gold-standard ...
Rajendran Sanalkumar, Jin Soo Kim, Chandler Zuo, Yoon-A Kang, Sunduz Keles, Prithvia Devadas, Duk Hyoung Kim, Emery H. Bresnick, Kyle J. Hewitt, Rajalekshmi Prathibha, Kirby D Johnson, Colin N. Dewey   +11 more
core   +1 more source

Interplay Between Ribosomal Gene Deficiency and Calorie Restriction in Shaping Yeast Biosynthetic Capacity

Cells
Biosynthetic capacity, particularly in protein production, significantly influences cells’ physiological efficiency and their ability to proliferate.
Roman Maslanka, Renata Zadrag-Tecza
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Sibling cell size matters

eLife, 2017
A motor protein called Klp10A ensures that germline stem cells in male fruit flies divide to produce two sibling cells that are equal in size.
openaire   +4 more sources