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What programs the size of animal cells?
Frontiers in Cell and Developmental Biology, 2022 The human body is programmed with definite quantities, magnitudes, and proportions. At the microscopic level, such definite sizes manifest in individual cells - different cell types are characterized by distinct cell sizes whereas cells of the same type ...
Shixuan Liu +8 more
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The Regulation of Cell Size [PDF]
Cell, 2013 An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood. Recent studies uncovering some of the signaling pathways important for size/growth control, together with the identification of diseases resulting from aberrations in these pathways, have renewed interest in this field ...
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Cell Cycle, 2007 Cell size plays an indirect role in cell proliferation, as cells must double in size before dividing. Cell size is largely determined by the activity of RNA polymerase I that controls ribosomal RNA synthesis and ribosome biogenesis. The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1 ...
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mTORC2 controls neuron size and Purkinje cell morphology independent of mTORC1 [PDF]
, 2012 Prenatal brain development is mainly accomplished by extensive proliferation of neuronal precursor cells whereas postnatal brain growth in mammals is mainly mediated by the growth of those post-mitotic nerve cells.
Thomanetz, Venus
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Plant Production Science, 2019 Endoreduplication is the phenomenon by which cells increase their ploidy. Endoreduplication is initiated by the transition from the mitotic cell cycle to the endocycle, in which DNA replication occurs without a subsequent chromosome separation and ...
Hidekazu Kobayashi
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Cell size, body size and Peto’s paradox
BMC Ecology and Evolution, 2022 AbstractCarcinogenesis is one of the leading health concerns afflicting presumably every single animal species, including humans. Currently, cancer research expands considerably beyond medicine, becoming a focus in other branches of natural science.
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A Cell Size Theory of Aging [PDF]
Developmental Cell, 2018 The factors determining longevity of different animals are incompletely defined. In this issue of Developmental Cell, Anzi et al. (2018) show that distinct strategies for postnatal pancreatic growth operate in different mammals and correlate with lifespan, with short-lived species exhibiting increasing pancreatic cell size and long-lived animals ...
Krushna C, Patra, Nabeel, Bardeesy
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Cellularity of porcine adipose tissue: effects of growth and adiposity
Journal of Lipid Research, 1977 Adipose tissue, from two depots in pigs of three breeding groups with different propensities to fatten, was characterized in terms of weight of the adipose tissue organ, adipose cell number, and mean cell volume as determined by electronic counting of ...
R L Hood, C E Allen
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Cell Size Control in Yeast [PDF]
Current Biology, 2012 Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology. Despite extensive characterization of the cell-cycle regulatory network, the molecular mechanisms coupling cell growth to division, and thereby controlling cell size, have remained elusive.
Turner, Jonathan J. +2 more
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The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
Frontiers in Cell and Developmental Biology, 2017 Cell size is amenable by genetic and environmental factors. The highly conserved nutrient-responsive Target of Rapamycin (TOR) signaling pathway regulates cellular metabolic status and growth in response to numerous inputs.
Suam Gonzalez, Charalampos Rallis
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